TRIM24 Protein (AA 862-980) (His tag,DYKDDDDK Tag)
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- 抗原 See all TRIM24 蛋白
- TRIM24 (Tripartite Motif Containing 24 (TRIM24))
- 蛋白类型
- Recombinant
- 产品特性
- AA 862-980
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This TRIM24 protein is labelled with His tag,DYKDDDDK Tag.
- 应用范围
- Binding Studies (Bind), Screening Assay (ScA)
- 产品特性
- The peptide corresponding to amino acids 862 - 980 that contains the bromodomain sequences of TRIM24 (accession number NM_003852.3) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 18.8 kDa. It shows binding specificity for acetylated H3K9, H3K14 and H3K16.
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- Discover our top product TRIM24 蛋白
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Tripartite Motif Containing 24 (TRIM24) (AA 1-1050) protein (GST tag)
TRIM24 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Tripartite Motif Containing 24 (TRIM24) (AA 896-1014) protein (His tag)TRIM24 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Tripartite Motif Containing 24 (TRIM24) (AA 432-569) protein (GST tag)TRIM24 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Tripartite Motif Containing 24 (TRIM24) (AA 1-1050) protein (Strep Tag)Crystallography grade TRIM24 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Tripartite Motif Containing 24 (TRIM24) (AA 1-1051) protein (Strep Tag)Crystallography grade TRIM24 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Tripartite Motif Containing 24 (TRIM24) (AA 891-1012), (partial) protein (His-SUMO Tag)TRIM24 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
Tripartite Motif Containing 24 (TRIM24) (AA 891-1012), (partial) protein (His tag)TRIM24 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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- 应用备注
- Recombinant TRIM24 (862-980) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- TRIM24 (Tripartite Motif Containing 24 (TRIM24))
- 别名
- TRIM24 (TRIM24 产品)
- 别名
- TRIM24 Protein, PTC6 Protein, RNF82 Protein, TF1A Protein, TIF1 Protein, TIF1A Protein, TIF1ALPHA Protein, hTIF1 Protein, ptc6 Protein, rnf82 Protein, tf1a Protein, tif1 Protein, tif1a Protein, tif1alpha Protein, A130082H20Rik Protein, AI447469 Protein, D430004I05Rik Protein, TIF1-alpha Protein, TIF1alpha Protein, Tif1a Protein, tripartite motif containing 24 Protein, transcription intermediary factor 1-alpha Protein, tripartite motif containing 24 S homeolog Protein, tripartite motif-containing 24 Protein, TRIM24 Protein, trim24 Protein, LOC100548578 Protein, trim24.S Protein, Trim24 Protein
- 背景
- Tripartite motif-containing 24 (TRIM24) protein, also known as TIF1α, is a member of the transcriptional intermediary factor 1 (TIF1) family that control transcription and chromatin remodeling through their interaction with transcription factors. The family includes TRIM24 (TIF1α), TRIM28 (TIF1β) and TRIM33 (TIF1γ) that share a characteristic domain structure comprised of multiple histone-binding domains, an N-terminal TRIM region (containing a RING domain, B box type 1 and type 2 domains, and a coiled-coil region), and a C-terminal bromodomain and PHD finger. Bromodomains function as 'readers' of epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. TRIM24 interacts with chromatin through recognition of specific histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at lysine 4 (H3K4me0) and acetylated at lysine 23 (H3K23ac). TRIM24 is an E3 ubiquitin-protein ligase that promotes proteosomal degradation of p53/TP53 and, in conjunction with TRIM33, mediates cell proliferation and apoptosis. TRIM24 also modulates transcriptional activation by retinoic acid (RA) receptors, including RARA, and has been shown to regulate RA-dependent proliferation of hepatocytes. TRIM24 functions as a transcriptional coactivator that interacts with the AF2 region of numerous nuclear receptors, including estrogen, RA and vitamin D3 receptors, and coactivators to modulate the transcription of target genes. It has been shown to be involved in upregulating ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1.
- 分子量
- 18.8 kDa
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