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Mesothelin Protein (MSLN) (AA 296-580) (Fc Tag,Biotin)

MSLN 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN2444166
发货至: 中国
  • 抗原 See all Mesothelin (MSLN) 蛋白
    Mesothelin (MSLN)
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 296-580
    宿主
    • 48
    • 14
    • 4
    • 2
    资源
    • 45
    • 8
    • 7
    • 4
    • 2
    • 2
    HEK-293 Cells
    标记
    This Mesothelin protein is labelled with Fc Tag,Biotin.
    品牌
    MABSol®,UltraLys
    序列
    AA 296-580
    特异性
    The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
    产品特性
    This protein carries a human IgG1 Fc fragment at the N-terminus. The protein has a calculated MW of 59.6 kDa. The protein migrates as 60-68 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product MSLN 蛋白
  • 说明

    A chemically labeled biotinylated protein with ultra sensitivity.
    The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
    Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity.

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
  • Sirois, Deny, Li, Fall, Moore: "Engineered Fn3 protein has targeted therapeutic effect on mesothelin-expressing cancer cells and increases tumor cell sensitivity to chemotherapy." in: Biotechnology and bioengineering, (2019) (PubMed).

    Sirois, Deny, Baierl, George, Moore: "Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding." in: PLoS ONE, Vol. 13, Issue 5, pp. e0197029, (2018) (PubMed).

  • 抗原
    Mesothelin (MSLN)
    别名
    Mesothelin (MSLN 产品)
    别名
    MPF Protein, SMRP Protein, MSLN Protein, mesothelin Protein, MSLN Protein, Msln Protein, LOC611363 Protein, LOC100524016 Protein
    背景
    Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
    分子量
    59.1 kDa
    途径
    EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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