R-Spondin 3 Protein (RSPO3) (AA 22-146) (His tag)
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- 抗原 See all R-Spondin 3 (RSPO3) 蛋白
- R-Spondin 3 (RSPO3)
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-146
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This R-Spondin 3 protein is labelled with His tag.
- 序列
- AA 22-146
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.3 kDa. The protein migrates as 18 kDa and 24 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
- 纯度
- >90 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product RSPO3 蛋白
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R-Spondin 3 (RSPO3) (AA 24-272) protein (His-IF2DI Tag)
RSPO3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
R-Spondin 3 (RSPO3) (AA 22-272) protein (His tag)Crystallography grade RSPO3 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
R-Spondin 3 (RSPO3) (AA 22-277) protein (His tag)Crystallography grade RSPO3 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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- 抗原
- R-Spondin 3 (RSPO3)
- 别名
- R-Spondin 3 (RSPO3 产品)
- 别名
- pwtsr Protein, thsd2 Protein, cristin1 Protein, CRISTIN1 Protein, PWTSR Protein, THSD2 Protein, RGD1563246 Protein, 2810459H04Rik Protein, AW742308 Protein, Cristin1 Protein, Thsd2 Protein, R-spondin 3 Protein, rspo3 Protein, RSPO3 Protein, Rspo3 Protein
- 背景
- R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.
- 分子量
- 15.9 kDa
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