电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

IL4 Receptor Protein (AA 26-232) (His tag)

IL4R 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
产品编号 ABIN2181320
发货至: 中国
  • 抗原 See all IL4 Receptor (IL4R) 蛋白
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 26-232
    宿主
    • 22
    • 11
    • 7
    • 5
    • 4
    • 1
    资源
    • 22
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    HEK-293 Cells
    标记
    This IL4 Receptor protein is labelled with His tag.
    序列
    AA 26-232
    产品特性
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.5 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    纯度
    >95 % as determined by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product IL4R 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
  • 抗原
    IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
    别名
    IL-4 R alpha (IL4R 产品)
    别名
    IL4R Protein, il-4ra Protein, zgc:113063 Protein, CD124 Protein, IL-4RA Protein, IL4RA Protein, Il4ra Protein, IL4 Protein, Il4r Protein, interleukin 4 receptor Protein, interleukin 4 receptor, tandem duplicate 1 Protein, interleukin 4 receptor, alpha Protein, IL4R Protein, il4r.1 Protein, Il4r Protein, Il4ra Protein
    背景
    IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2--biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL-13Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13. Interleukin-4 receptor has been shown to interact with SHC1.
    分子量
    24.6 kDa
    NCBI登录号
    NP_000409
    途径
    JAK/STAT Signaling, Positive Regulation of Immune Effector Process
You are here:
客服