Sonic Hedgehog Protein (SHH) (AA 25-198)
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- 抗原 See all Sonic Hedgehog (SHH) 蛋白
- Sonic Hedgehog (SHH)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 25-198
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宿主
- 小鼠
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资源
- CHO Cells
- 产品特性
- ED50 < 1 μg/mL, measured by its ability to induce alkaline phosphatase production by CCL-226 cells, corresponding to a specific activity of >1 x 10^3 units/mg.
- 纯度
- > 95 % as analyzed by SDS-PAGE and HPLC.
- 内毒素水平
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product SHH 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- 缓冲液
- Lyophilized after extensive dialysis against PBS.
- 储存条件
- -80 °C
- 储存方法
- Lyophilized recombinant Murine Sonic Hedgehog (SHH) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rmSHH should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
- 有效期
- 6 months
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- 抗原
- Sonic Hedgehog (SHH)
- Abstract
- SHH 产品
- 别名
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- 背景
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Members of the Hedgehog (Hh) family are highly conserved proteins which are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh) are structurally related and share a high degree of amino-acid sequence identity (e.g., Shh and Ihh are 93 % identical). The biologically active form of Hh molecules is obtained by autocatalytic cleavage of their precursor proteins and corresponds to approximately the N-terminal one half of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can substitute for each other in experimental systems. Recombinant E. coli derived Human Sonic HedgeHog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the natural occurring chemically modified Cys residue.
Synonyms: SHH, HHG-1 - 分子量
- 20 kDa, observed by non-reducing SDS-PAGE.
- UniProt
- Q62226
- 途径
- Hedgehog Signaling, Dopaminergic Neurogenesis, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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