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ABCB5 Protein (AA 141-247) (TRX tag)

ABCB5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN1692397
发货至: 中国
  • 抗原 See all ABCB5 蛋白
    ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
    蛋白类型
    Recombinant
    产品特性
    AA 141-247
    宿主
    • 6
    • 1
    资源
    • 3
    • 2
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This ABCB5 protein is labelled with TRX tag.
    原理
    Recombinant Human ATP-binding Cassette B5/ABCB5 (N-Trx)
    序列
    MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY QGKLTVAKLN IDQNPGTAPK YGIRGIPTLL LFKNGEVAAT KVGALSKGQL KEFLDANLAG SGSGHMHHHH HHSSGLVPRG SGMKETAAAK FERQHMDSPD LGTDDDDKAM AIRSADLIVT LKDGMLAEKG AHAELMAKRG LYYSLVMSQD IKKADEQMES MTYSTERKTN SLPLHSVKSI KSDFIDKAEE STQSKEISLP EVSLLKILKL NKPEWPFV
    产品特性
    Recombinant Human ATP-binding cassette sub-family B member 5/ABCB5 is produced with our E. coli expression system. The target protein is expressed with sequence (Ile141-Val247) of Human ABCB5 fused with a Trx tag at the N-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    过滤
    0.2 μm filtered
    内毒素水平
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product ABCB5 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    注意事项
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    储存条件
    4 °C/-20 °C/-80 °C
    储存方法
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    有效期
    5 months
  • 抗原
    ABCB5 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 5 (ABCB5))
    别名
    ABCB5 (ABCB5 产品)
    别名
    ABCB5alpha Protein, ABCB5beta Protein, EST422562 Protein, 9230106F14Rik Protein, RGD1566342 Protein, ABCB5 Protein, mdr1 Protein, im:7158730 Protein, wu:fc18f02 Protein, wu:fi81f06 Protein, ATP binding cassette subfamily B member 5 Protein, ATP-binding cassette, sub-family B (MDR/TAP), member 5 Protein, ATP-binding cassette sub-family B member 5 Protein, ABCB5 Protein, Abcb5 Protein, abcb5 Protein, TGME49_249820 Protein, PAAG_04387 Protein, VDBG_00160 Protein, VDBG_02292 Protein
    Sub Type
    Fusionprotein
    背景
    ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.
    Alternative Names: ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5,
    分子量
    29.4 kDa
    UniProt
    Q2M3G0
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