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IL-18 Protein (AA 37-193) (His tag)

IL18 宿主: 人 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN1691766
发货至: 中国
  • 抗原 See all IL-18 (IL18) 蛋白
    IL-18 (IL18) (Interleukin 18 (IL18))
    蛋白类型
    Recombinant
    产品特性
    AA 37-193
    宿主
    • 19
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    资源
    • 30
    • 9
    • 3
    • 1
    • 1
    人细胞
    标记
    This IL-18 protein is labelled with His tag.
    原理
    Recombinant Human Interleukin-18/IL-18/IL-1F4 (C-6His)
    序列
    YFGKLESKLS VIRNLNDQVL FIDQGNRPLF EDMTDSDCRD NAPRTIFIIS MYKDSQPRGM AVTISVKCEK ISTLSCENKI ISFKEMNPPD NIKDTKSDII FFQRSVPGHD NKMQFESSSY EGYFLACEKE RDLFKLILKK EDELGDRSIM FTVQNEDVDH HHHHH
    产品特性

    Recombinant Human Interleukin-18/IL-18/IL-1F4 (C-6His)

    纯度
    > 95 % as determined by reducing SDS-PAGE.
    过滤
    0.2 μm filtered
    内毒素水平
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product IL18 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    注意事项
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    储存条件
    4 °C/-20 °C/-80 °C
    储存方法
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • 抗原
    IL-18 (IL18) (Interleukin 18 (IL18))
    别名
    Interleukin-18/IL-18 (IL18 产品)
    别名
    Igif Protein, Il-18 Protein, IL-18 Protein, IGIF Protein, ChIL-18 Protein, IL-1g Protein, IL1F4 Protein, IL18 Protein, interleukin 18 Protein, Il18 Protein, IL18 Protein
    背景
    Recombinant Human Interleukin-18/IL-18 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr37-Asp193) of Human IL-18 fused with a polyhistidine tag at the C-terminus.
    Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-γ production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
    分子量
    23.3 kDa
    UniProt
    Q14116
    途径
    Cellular Response to Molecule of Bacterial Origin, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
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