抗原 See all CYR61 蛋白: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
蛋白类型: Recombinant
产品特性: AA 1-381
宿主 8 4 1 1 1: 人
资源 5 4 2 2 2: 小麦胚
标记: This CYR61 protein is labelled with GST tag.
应用范围: Western Blotting (WB), ELISA, Antibody Array (AA), Affinity Purification (AP)
原理: CYR61 (Human) Recombinant Protein (P01)
序列: MSSRIARALA LVVTLLHLTR LAPSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSIKD PMEDQDGLLG KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLQGQKCI VQTTSWSQCS KTCGTGISTR VTNDNPECRL VKETRICKVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY AGCLSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D
产品特性: Human CYR61 full-length ORF ( AAH01271.1, 1 a.a. - 381 a.a.) recombinant protein with GST-tag at N-terminal.
纯化方法: in vitro wheat germ expression system

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (His tag)

CYR61 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (GST tag)

CYR61 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 293-381) protein (GST tag)

CYR61 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (His tag)

Crystallography grade CYR61 宿主: 人宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-379) protein (His tag)

Crystallography grade CYR61 宿主: 小鼠宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) protein (Fc Tag)

CYR61 宿主: 人宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) protein

CYR61 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant SDS

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 176-379) protein (His tag)

CYR61 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant > 97 % WB, SDS, Imm, PC

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (Fc Tag)

CYR61 宿主: 人宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.

Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 178-381) protein (His tag)

CYR61 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, Imm, PC

应用备注: Optimal working dilution should be determined by the investigator.
说明: Preparation method: in vitro, wheat germ expression system
Product Quality tested by: 12.5% SDS-PAGE Stained with Coomassie Blue.
限制: 仅限研究用

缓冲液: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.
注意事项: Aliquot to avoid repeated freezing and thawing.
储存条件: -80 °C
储存方法: Best use within three months from the date of receipt of this protein.

Jeansonne, Pacifici, Lassak, Reiss, Russo, Zabaleta, Peruzzi: "Differential Effects of MicroRNAs on Glioblastoma Growth and Migration." in: Genes, Vol. 4, Issue 1, pp. 46-64, (2014) (PubMed).

Kok, Lin, Hou, Hong, Chang, Hsiao, Wang, Lai, Lin: "Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling." in: Arthritis and rheumatism, Vol. 65, Issue 3, pp. 639-49, (2013) (PubMed).

You, Yang, Yang, Chen: "Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin ???3, FAK, PI3K/Akt, and NF-?B pathways in retinal vascular endothelial cells." in: Cellular signalling, Vol. 26, Issue 1, pp. 133-40, (2013) (PubMed).

Terada, Shiraishi, Zeng, Mooney, Yeater, Mangold, Partin, Kulkarni, Getzenberg: "Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness." in: The Prostate, Vol. 72, Issue 9, pp. 966-76, (2012) (PubMed).

Wu, Lin, Lee, Kok, Wang, Hou, Yang, Lai, Wang, Hong: "Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis." in: Rheumatology (Oxford, England), Vol. 51, Issue 11, pp. 1953-65, (2012) (PubMed).

Kok, Hou, Hong, Wang, Liang, Chang, Hsiao, Yang, Lai, Lin: "Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis." in: Arthritis and rheumatism, Vol. 63, Issue 4, pp. 1010-20, (2011) (PubMed).

Bär, Dorfman, Fischer, Hilfiker-Kleiner, Cebotari, Tudorache, Suprunov, Haverich, Hilfiker: "The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro." in: Cardiovascular research, Vol. 85, Issue 4, pp. 806-13, (2010) (PubMed).

Su, Chiou, Tang, Zhao, Tsai, Chen, Chang, Chien, Peng, Hsiao, Kuo, Yen: "CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31325-36, (2010) (PubMed).

You, Yang, Chen, Yang: "Regulation of Cyr61/CCN1 expression by hypoxia through cooperation of c-Jun/AP-1 and HIF-1? in retinal vascular endothelial cells." in: Experimental eye research, Vol. 91, Issue 6, pp. 825-36, (2010) (PubMed).

Chai, Norng, Modak, Reavis, Mouazzen, Pham: "CCN1 induces a reversible epithelial-mesenchymal transition in gastric epithelial cells." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 90, Issue 8, pp. 1140-51, (2010) (PubMed).

You, Yang, Chen, Yang: "Cysteine-rich 61, a member of the CCN family, as a factor involved in the pathogenesis of proliferative diabetic retinopathy." in: Investigative ophthalmology & visual science, Vol. 50, Issue 7, pp. 3447-55, (2009) (PubMed).

Lin, Kuo, Chang, Chu, Chen, Lin, Sureshbabu, Shih, Kuo: "Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15807-15, (2008) (PubMed).

Grote, Salguero, Ballmaier, Dangers, Drexler, Schieffer: "The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration." in: Blood, Vol. 110, Issue 3, pp. 877-85, (2007) (PubMed).

Athanasopoulos, Schneider, Keiper, Alt, Pendurthi, Liegibel, Sommer, Nawroth, Kasperk, Chavakis: "Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing." in: The Journal of biological chemistry, Vol. 282, Issue 37, pp. 26746-53, (2007) (PubMed).

Lin, Chang, Chen, Wu, Wang, Kuo, Chu, Chang, Lee, Chen, Kuo, Lin: "Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2." in: Molecular cancer research : MCR, Vol. 5, Issue 11, pp. 1111-23, (2007) (PubMed).

OConnor, Mills, Jones, Ho, Pavlath: "A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis." in: Journal of cell science, Vol. 120, Issue Pt 1, pp. 149-59, (2006) (PubMed).

抗原: CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
别名: CYR61 (CYR61 产品)
别名: CCN1 Protein, GIG1 Protein, IGFBP10 Protein, ccn1 Protein, gig1 Protein, Xcyr61 Protein, igfbp10 Protein, MGC69281 Protein, MGC69539 Protein, cyr61-l2 Protein, zgc:158158 Protein, CYR61 Protein, AI325051 Protein, Igfbp10 Protein, cysteine rich angiogenic inducer 61 Protein, cysteine-rich, angiogenic inducer, 61 Protein, cysteine-rich, angiogenic inducer, 61 like 2 Protein, cysteine rich protein 61 Protein, cysteine rich angiogenic inducer 61 S homeolog Protein, CYR61 Protein, Cyr61 Protein, cyr61 Protein, cyr61l2 Protein, cyr61.S Protein
背景: Full Gene Name: cysteine-rich, angiogenic inducer, 61
Synonyms: CCN1,GIG1,IGFBP10
基因ID: 3491
途径: Positive Regulation of Endopeptidase Activity, Growth Factor Binding

CYR61 Protein (AA 1-381) (GST tag)

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