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TRAIL Protein (AA 95-281, Extracellular Domain, Soluble) (DYKDDDDK Tag)

TNFSF10 宿主: 人, 小鼠 宿主: 大肠杆菌(E. Coli) Recombinant >95 % (SDS-PAGE) SDS Active
产品编号 ABIN1344414
发货至: 中国
  • 抗原 See all TRAIL (TNFSF10) 蛋白
    TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    Soluble, Extracellular Domain, AA 95-281
    宿主
    • 23
    • 7
    • 2
    • 1
    人, 小鼠
    资源
    • 25
    • 2
    • 2
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This TRAIL protein is labelled with DYKDDDDK Tag.
    应用范围
    SDS-PAGE (SDS)
    交叉反应
    人, 小鼠
    产品特性
    The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a FLAG®-tag.
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product TNFSF10 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Induces apoptosis of human Jurkat T cells in a concentration range of 5-50ng/ml in the presence of 1μg/ml TNF Ligands Enhancer (Prod. No. AG-35B-0001). In the absence of TNF Ligands Enhancer, TRAIL, Soluble (human) (recombinant) is poorly active.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute with 100 μL sterile water.
    浓度
    Lot specific
    缓冲液
    Lyophilized. Contains PBS.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • 抗原
    TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
    别名
    TRAIL (TNFSF10 产品)
    别名
    APO2L Protein, Apo-2L Protein, CD253 Protein, TL2 Protein, TRAIL Protein, A330042I21Rik Protein, AI448571 Protein, APO-2L Protein, Ly81 Protein, Trail Protein, tl2 Protein, apo2l Protein, cd253 Protein, trail Protein, apo-2l Protein, trail1 Protein, xtrail1 Protein, tnfsf10l2 Protein, zgc:92320 Protein, TNLG6A Protein, TNF superfamily member 10 Protein, tumor necrosis factor (ligand) superfamily, member 10 Protein, tumor necrosis factor superfamily member 10 Protein, TNF superfamily member 10 S homeolog Protein, TNFSF10 Protein, Tnfsf10 Protein, tnfsf10.S Protein, tnfsf10 Protein
    背景
    TNF-related apoptosis-inducing ligand (TRAIL, Apo2L,CD253, TNFSF10) is a type II transmembrane protein of about 34 kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to fi ve distinct receptors: TRAIL-R1 (DR4, Apo2,CD261, TNFRSF10A), TRAIL-R2 (DR5, KILLER, TRICK2A,TRICK2B, CD262, TNFRSF10B), TRAIL-R3 (DcR1,LIT, TRID, CD263, TNFRSF10C), TRAIL-R4 (DcR2,TRUNDD, CD264, TNFRSF10D), and osteoprotegerin (OPG, OCIF, TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducingthe formation of the so-called multiprotein death-inducing signaling complex (DISC).
    分子量
    ~23kDa (SDS-PAGE)
    UniProt
    P50591
    途径
    Apoptosis, Positive Regulation of Endopeptidase Activity
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