HES1 Protein (AA 2-280) (His tag)
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- 抗原 See all HES1 蛋白
- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-280
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This HES1 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 交叉反应
- 人
- 产品特性
- Human HES1 (aa 2-280) is fused at the N-terminus to a His-tag.
- 纯度
- >90 % (SDS-PAGE)
- 过滤
- 0.2 μm filtered
- Top Product
- Discover our top product HES1 蛋白
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Hes Family bHLH Transcription Factor 1 (HES1) (AA 36-142) protein (GST tag)
HES1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hes Family bHLH Transcription Factor 1 (HES1) (AA 201-280) protein (GST tag)HES1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hes Family bHLH Transcription Factor 1 (HES1) (AA 1-277) protein (GST tag)HES1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Hes Family bHLH Transcription Factor 1 (HES1) (AA 1-280) protein (Strep Tag)Crystallography grade HES1 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Hes Family bHLH Transcription Factor 1 (HES1) (AA 1-282) protein (Strep Tag)Crystallography grade HES1 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Hes Family bHLH Transcription Factor 1 (HES1) protein (Myc-DYKDDDDK Tag)HES1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - 有效期
- 3 months
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- 抗原
- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
- 别名
- HES1 (HES1 产品)
- 别名
- HES-1 Protein, HHL Protein, HRY Protein, bHLHb39 Protein, Hry Protein, HAIRY1 Protein, c-hairy1A Protein, Xhairy1 Protein, hairy1 Protein, hes1 Protein, Xhairy-1 Protein, Xlh1 Protein, hes family bHLH transcription factor 1 Protein, hairy and enhancer of split 1 (Drosophila) Protein, hes family bHLH transcription factor 4 Protein, hes family bHLH transcription factor 1 S homeolog Protein, hes family bHLH transcription factor 1 L homeolog Protein, HES1 Protein, Hes1 Protein, HES4 Protein, hes1.S Protein, hes1.L Protein
- 背景
- BHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
- 分子量
- ~35kDa (SDS-PAGE)
- UniProt
- Q14469
- 途径
- DNA Damage Repair
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