BCMA Protein (AA 2-54, Extracellular Domain) (Fc Tag)
(4 references)-
- 抗原 See all BCMA (TNFRSF17) 蛋白
- BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Extracellular Domain, AA 2-54
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宿主
- 人, 小鼠
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资源
- HEK-293 Cells
- 标记
- This BCMA protein is labelled with Fc Tag.
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds human and mouse BAFF and APRIL.
- 交叉反应
- 人, 小鼠
- 产品特性
- The extracellular domain of human BCMA (aa 2-54) is fused at the C-terminus to the Fc portion of human IgG1.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF17 蛋白
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Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-54) protein (Fc Tag)
TNFRSF17 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (Trimer) protein (His-Avi Tag)TNFRSF17 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-53) protein (Fc Tag)TNFRSF17 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-49) protein (His-Avi Tag)TNFRSF17 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-49) protein (His-Avi Tag,Biotin)TNFRSF17 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) protein (mFc Tag)TNFRSF17 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-54) (Active) protein (Fc Tag)TNFRSF17 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-49) protein (Fc Tag)TNFRSF17 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (Trimer) protein (His-Avi Tag,Biotin)TNFRSF17 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) (AA 1-54) (Active) protein (His tag)TNFRSF17 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 50 μL sterile water.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).
: "BAFF production by antigen-presenting cells provides T cell co-stimulation." in: International immunology, Vol. 16, Issue 3, pp. 467-75, (2004) (PubMed).
: "T cell costimulation by the TNF ligand BAFF." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6225-31, (2001) (PubMed).
: "A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth." in: The Journal of experimental medicine, Vol. 192, Issue 11, pp. 1677-84, (2000) (PubMed).
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: "Selective APRIL blockade delays systemic lupus erythematosus in mouse." in: PLoS ONE, Vol. 7, Issue 2, pp. e31837, (2012) (PubMed).
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- 抗原
- BCMA (TNFRSF17) (Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17))
- 别名
- BCMA (TNFRSF17 产品)
- 别名
- TNFRSF17 Protein, BCM Protein, BCMA Protein, CD269 Protein, TNFRSF13A Protein, Tnfrsf13 Protein, Tnfrsf13a Protein, TNF receptor superfamily member 17 Protein, tumor necrosis factor receptor superfamily, member 17 Protein, Tnfrsf17 Protein, TNFRSF17 Protein
- 背景
- BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. Its downstream signaling is dependent on NF-kappaB and JNK.
- 分子量
- ~40kDa (SDS-PAGE)
- UniProt
- Q02223
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