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Netrin 1 Protein (NTN1) (AA 25-604) (Fc Tag)

NTN1 宿主: 小鼠, 人, 大鼠 宿主: HEK-293 Cells Recombinant >95 % (SDS-PAGE) SDS Active
产品编号 ABIN1344145
发货至: 中国
  • 抗原 See all Netrin 1 (NTN1) 蛋白
    Netrin 1 (NTN1)
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 25-604
    宿主
    • 6
    • 5
    • 4
    • 2
    小鼠, 人, 大鼠
    资源
    • 9
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This Netrin 1 protein is labelled with Fc Tag.
    应用范围
    SDS-PAGE (SDS)
    特异性
    Binds to human, mouse and rat UNC5B.
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Human netrin-1 (aa 25-604) is fused at the C-terminus to the Fc portion of human IgG1.
    纯度
    >95 % (SDS-PAGE)
    内毒素水平
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product NTN1 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150ng /ml). Induces axon outgrowth.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute with 100 μL sterile distilled water.
    浓度
    Lot specific
    缓冲液
    Lyophilized. Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    有效期
    6 months
  • Rama, Goldschneider, Corset, Lambert, Pays, Mehlen: "Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth." in: The Journal of biological chemistry, Vol. 287, Issue 35, pp. 30014-23, (2012) (PubMed).

    Castets, Broutier, Molin, Brevet, Chazot, Gadot, Paquet, Mazelin, Jarrosson-Wuilleme, Scoazec, Bernet, Mehlen: "DCC constrains tumour progression via its dependence receptor activity." in: Nature, Vol. 482, Issue 7386, pp. 534-7, (2012) (PubMed).

  • 抗原
    Netrin 1 (NTN1)
    别名
    Netrin-1 (NTN1 产品)
    别名
    ntn1-A Protein, Netrin-1 Protein, NTN1 Protein, unc-6 Protein, MGC147073 Protein, NTN1L Protein, AI561871 Protein, BC019633 Protein, netrin-1 Protein, netrin 1 L homeolog Protein, netrin 1 Protein, ntn1.L Protein, NTN1 Protein, ntn1 Protein, Ntn1 Protein
    背景
    Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.
    分子量
    ~90kDa (SDS-PAGE)
    UniProt
    O95631
    途径
    Regulation of Cell Size
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