c-MYC Protein (AA 1-439) (His tag)
(3 references)-
- 抗原 See all c-MYC (MYC) 蛋白
- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-439
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This c-MYC protein is labelled with His tag.
- 应用范围
- ELISA, SDS-PAGE (SDS)
- 序列
- MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP LSPSRRSGLC SPSYVAVTPF SLRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPNPARGHSV CSTSSLYLQD LSAAASECID PSVVFPYPLN DSSSPKSCAS QDSSAFSPSS DSLLSSTESS PQGSPEPLVL HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QAPGKRSESG SPSAGGHSKP PHSPLVLKRC HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENVKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAEE QKLISEEDLL RKRREQLKHK LEQLRNSCA
- 产品特性
- Recombinant full-length human Myc proto-oncogene protein (MYC) cDNA (439 aa) constructed with a 6xHis-tag at the N-terminus was expressed in E. coli. It got purified up to 90% as determined by SDS-PAGE. Its predicted molecular weight is 52.8 kDa, but the observed is about 60 kDa. Posttranslational modification results in the higher actual molecular weight.
- 纯度
- Greater than 90% as determined by SDS-PAGE.
- Top Product
- Discover our top product MYC 蛋白
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Myc Proto-Oncogene protein (MYC) (AA 1-439) protein (GST tag)
MYC 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Myc Proto-Oncogene protein (MYC) (AA 330-439) protein (GST tag)MYC 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
Myc Proto-Oncogene protein (MYC) protein (Myc-DYKDDDDK Tag)MYC 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Myc Proto-Oncogene protein (MYC) (AA 1-454) protein (His tag)MYC 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Myc Proto-Oncogene protein (MYC) (AA 1-439) protein (His tag)Crystallography grade MYC 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Myc Proto-Oncogene protein (MYC) (AA 1-439) protein (His tag)Crystallography grade MYC 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Myc Proto-Oncogene protein (MYC) (AA 1-439), (full length) protein (His tag)MYC 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 应用备注
- This MYC protein may find uses on specific antibody production, iPS generation mechanism mediated by human MYC in vitro, or related signaling transduction.
- 说明
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Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.
- 缓冲液
- If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
- 注意事项
- Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
- 储存条件
- -20 °C/-80 °C
- 储存方法
- Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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: "Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours." in: The EMBO journal, Vol. 2, Issue 12, pp. 2375-83, (1984) (PubMed).
: "The human c-myc oncogene: structural consequences of translocation into the IgH locus in Burkitt lymphoma." in: Cell, Vol. 34, Issue 3, pp. 779-87, (1983) (PubMed).
: "Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29." in: Nature, Vol. 301, Issue 5902, pp. 722-5, (1983) (PubMed).
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: "Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours." in: The EMBO journal, Vol. 2, Issue 12, pp. 2375-83, (1984) (PubMed).
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- 抗原
- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
- Abstract
- MYC 产品
- 背景
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Synonyms: Class E basic helix-loop-helix protein 39,bHLHe39,Proto-oncogene c-Myc,Transcription factor p64
MYC is an oncoprotein that plays a central role in almost the whole oncogenic process, orchestrating proliferation, apoptosis, differentiation, and metabolism. As a transcription factor, MYC regulates transcription of numerous specific target genes that are involved in distinct cellular functions, such as cell cycle, protein biosynthesis, cell adhesion and cytoskeleton, metabolism, signal transduction, transcription, and translation. Aberrations in MYC protein, including mutations, overexpression, rearrangement, and translocation, have been linked to various hematopoietic tumors, leukemias, and lymphomas. - 分子量
- 52.8 kDa
- UniProt
- P01106
- 途径
- p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
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