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Detection of functional V(H)81X heavy chains in adult mice with an assessment of complementarity-determining region 3 diversity and capacity to form pre-B cell receptor.
Pre-B cell receptor (BCR) signals establish the molecular network for BCR signaling even before the production of an IgL Chain and induce the expression of KLF2, a candidate for controlling clonal expansion and migration of functional pre-B cells.
levels of VPREB3 mRNA in aldosterone-producing adenomas directly correlate to plasma aldosterone concentrations in peripheral blood of respective patients
mouse VpreB3 associates with mu heavy chains early in pre-B cell receptor biosynthesis
VpreB3 may play a role in the regulation of the maturation and secretion of free IgLC in chicken B cells
the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B-cell lymphomas.
Data show that the absence of VpreB3 is virtually always associated with wild-type c-MYC alleles.
the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation.
The protein encoded by this gene is the human homolog of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-cell differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. This protein associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of the protein is not known, but it may contribute to mu chain transport in pre-B cells.
pre-B lymphocyte protein 3
, pre-B lymphocyte gene 3
, pre-B lymphocyte 3