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MMP7 shedding of syndecan-1 (显示 SDC1 蛋白)/CXCL1 (显示 CXCL1 蛋白) complexes functions as a checkpoint that restricts neutrophil activation at sites of epithelial injury.
MMP7 exerts a restrictive role on H. pylori-induced gastric injury and the development of premalignant lesions by suppressing M1 macrophage polarization.
absence of MMP7 protects mice from LPS (显示 TLR4 蛋白)-induced intestinal permeability and lethality.
regulator of beta-catenin (显示 CTNNB1 蛋白) function in injured lung epithelium
Angiotensin II suppresses RECK (显示 RECK 蛋白), but induces matrix metalloproteinases both in vivo and in vitro.
MMP7 regulated ciliated cell formation.
SPARC (显示 SPARC 蛋白) suppresses angiogenesis of gastric cancer by down-regulating the expression of VEGF (显示 VEGFA 蛋白) and MMP-7
Protein expression levels of MMP-7, MMP-14 and ERK1/2 phosphorylation level were all elevated with the increasing pathological grades in brain glioma tissues.
levels of renal MMP-7 correlate with Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) activity.
STAT3 (显示 STAT3 蛋白) plays an important role in regulation of tumor growth, invasion, and angiogenesis, which could be act by reducing MMP-7 expression in pancreatic cancer cells.
Studies have identified an unexpected tumor-suppressive role for host-derived MMP-7 in myeloma bone disease in vivo, and highlight the importance of elucidating the effect of individual MMPs in a disease-specific context.
the crosstalk between ARF and MMP7 in nucleus contributes to ECM (显示 MMRN1 蛋白) network in tumor microenvironments in vivo, implicating a novel therapeutic target for advanced PCa (显示 FLVCR1 蛋白) treatment.
Data suggest that HAI1 (显示 SPINT1 蛋白), a protease on the surface of colon carcinoma cells, is an MMP7 substrate; proteolysis by MMP7 releases extracellular region as soluble HAI1 (显示 SPINT1 蛋白) (sHAI1); sHAI1 induces cancer cell aggregation; cholesterol sulfate is required for MMP-7--catalyzed generation of sHAI1. (HAI1 (显示 SPINT1 蛋白) = hepatocyte growth factor activator inhibitor type 1 (显示 SPINT1 蛋白); MMP7 = matrix metalloproteinase-7)
Results indicate that the matrix metallopeptidase 7 (MMP7)A-181G genotype interacts with age and gender and may serve as an early and predictive biomarker for childhood acute lymphoblastic leukemia (ALL).
The A/A genotype (OR=0.120) and A allele (OR=0.442) reduce the risk of recurrent depressive disorder occurrence in the examined polymorphisms for MMP-2 (显示 MMP2 蛋白), MMP-7 and MMP-9 (显示 MMP9 蛋白).
SLC12A5 (显示 SLC12A5 蛋白) promoted the migration and invasion of BUC by enhancing MMP-7 expression.
Overexpression of LAMC2 (显示 LAMC2 蛋白) and knockdown of CD82 (显示 CD82 蛋白) markedly promoted GC cell invasion and activated EGFR (显示 EGFR 蛋白)/ERK1/2-MMP7 signaling via upregulation of the expression of phosphorylated (p)-EGFR (显示 EGFR 蛋白), p-ERK1/2 and MMP7.
Matrix Metalloproteinase-7 Promoter polymorphism is associated with breast Cancer.
Data suggest that the cytoplasmic domain of Sdc2 (显示 SDC2 蛋白) is involved in regulation of expression of MMP7 in colon carcinoma/adenocarcinoma cells; induction of MMP7 involves protein kinase C gamma (显示 PRKCG 蛋白)-mediated FAK (显示 PTK2 蛋白)/ERK (显示 EPHB2 蛋白) signaling. (Sdc2 (显示 SDC2 蛋白) = syndecan-2 (显示 SDC2 蛋白); MMP7 = matrix metalloproteinase-7; FAK (显示 PTK2 蛋白) = focal adhesion kinase 1 (显示 PTK2 蛋白))
We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7, MMP-10 (显示 MMP10 蛋白) and TIMP-1 (显示 TIMP1 蛋白) correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease MMP-10 (显示 MMP10 蛋白), MMP-7, TIMP-1 (显示 TIMP1 蛋白), TIMP-2 (显示 TIMP2 蛋白) were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, matrilysin, uterine
, matrix metalloproteinase 7
, matrix metalloproteinase-7
, pump-1 protease
, uterine metalloproteinase
, Matrix metalloproteinase 7 (matrilysin)
, matrix metalloproteinase 7 (matrilysin, uterine)
, uterine matrilysin
, matrilysin-related protein