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The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (显示 JUN 蛋白), CEBPB (显示 CEBPB 蛋白), PRKCB (显示 PRKCB 蛋白), ENO2 (显示 ENO2 蛋白), or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
These findings suggest that CEBPG may play an oncogenic role in BCP (显示 OPN1SW 蛋白)-ALL and relies on a mechanism different from CEBPA (显示 CEBPA 蛋白).
HIV-1 Tat (显示 TAT 蛋白)-mediated induction of CCL5 (显示 CCL5 蛋白) in astrocytes involves NF-kappaB (显示 NFKB1 蛋白), AP-1 (显示 FOSB 蛋白), C/EBPalpha (显示 CEBPA 蛋白) and C/EBPgamma transcription factors and JAK (显示 JAK3 蛋白), PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) and p38 MAPK (显示 MAPK14 蛋白) signaling pathways
High CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBP gam (显示 CEBPB 蛋白)ma depletion decreased proliferation and induced senescence in lung tumor cells.
CEBPG mediates the myeloid differentiation arrest induced by CEBPA (显示 CEBPA 蛋白) deficiency in acute myeloid leukemia (显示 BCL11A 蛋白).
C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR (显示 EGFR 蛋白) signaling.
Ig/EBP (C/EBPgamma)is constitutively multiubiquitinated & then degraded by the proteasome. Ubiquitination and degradation are suppressed by forming dimers through the leucine zipper domains.
CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals
CEBPG regulates ERCC5 (显示 ERCC5 蛋白) expression and this regulation is modified by E2F1 (显示 E2F1 蛋白)/YY1 (显示 YY1 蛋白) interactions.
Adult Cebpg-/- mice on a mixed strain background show increased early mortality and altered cancer incidence.
HIV-1 Tat (显示 TAT 蛋白)-mediated induction of CCL5 (显示 CCL5 蛋白) in astrocytes involves NF-kappaB (显示 NFKB1 蛋白), AP-1 (显示 JUN 蛋白), C/EBPalpha (显示 CEBPA 蛋白) and C/EBPgamma transcription factors and JAK (显示 JAK3 蛋白), PI3K/Akt (显示 AKT1 蛋白) and p38 MAPK (显示 MAPK14 蛋白) signaling pathways
The senescence-suppressing activity of C/EBPgamma required its ability to heterodimerize with C/EBPbeta (显示 CEBPB 蛋白).
CCAAT/enhancer-binding protein gamma is a critical regulator of IL-1beta (显示 IL1B 蛋白)-induced IL-6 (显示 IL6 蛋白) production in alveolar epithelial cells.
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene.
CCAAT/enhancer-binding protein gamma
, CCAAT/enhancer binding protein (C/EBP), gamma
, leucine zipper transcription factor
, c/EBP gamma
, CCAAT/enhancer binding protein gamma
, G-CSF promoter element 1 binding protein
, GPE1-BP (C/EBP gamma)
, GPE1-binding protein
, granulocyte colony-stimulating factor promoter element 1-binding protein
, immunoglobulin enhancer-binding protein 1
, CCAAT/enhancer binding protein ,gamma
, homolog to a human CCAAT/enhancer binding protein - gamma