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Our studies revealed that KISS1 inhibits glycolysis and carbon sources for endogenous fatty acid oxidation (FAO).
KiSS1 gene is a novel mediator of TGFbeta (显示 TGFB1 蛋白)-mediated cell invasion in triple negative breast cancer.
Kisspeptin inhibited tumor growth through an EIF2AK2dependent mechanism, and an in vivo metastasis assay identified kisspeptinactivated EIF2AK2 (显示 EIF2AK2 蛋白) signaling as critical for the suppression of distant metastasis.
High plasma kisspeptin-1 is associated with premature thelarche.
Data suggest that subjects with anorexia nervosa display broad spectrum of physical activity (2479-26,047 steps/day) which shows a negative correlation with plasma kisspeptin levels and a positive association with plasma ghrelin (显示 GHRL 蛋白) levels.
Kisspeptin-10 may contribute to accelerate the progression and instability of atheromatous plaques, leading to plaque rupture. The GPR54 (显示 KISS1R 蛋白) antagonist may be useful for prevention and treatment of atherosclerosis.
we conclude that KISS-1 can inhibit the proliferation of osteosarcoma in vitro by accelerating the processes of apoptosis and autophagy.
These findings suggest that infundibular kisspeptin neurons are sensitive to circulating sex steroid hormones throughout life and that the sex reversal observed in MTF transsexuals might reflect, at least partially, an atypical brain sexual differentiation.
Patients with ovarian epithelial cancer and low KISS1 mRNA expression had shorter survival time than those with high expression (P = 0.001).Preoperative KISS1 mRNA was a potential prognostic biomarker for EOC, and high preoperative KISS1 expression indicated a favorable prognosis.
Lower expression of KiSS1 was observed in metastatic Breast Cancer.
kiss1 and ghrh3 double mutants retain reproductive capacity
results reveal the pattern of kisspeptin neurones and their connections with GnRH3 neurones in the brain, suggesting distinct mechanisms for Kiss1 and Kiss2 in regulating reproductive events in zebrafish.
These findings implicate that Kiss1 could modulate fear responses mediated by 5-HT1A and 5-HT2 receptors
These findings suggest that the autocrine-regulated habenular Kiss1 neurons indirectly regulate the serotonergic system in the raphe nuclei through the habenula-interpeduncular nucleus in the zebrafish.
Dada (显示 ADA 蛋白) show that kiss1-expressing neurons are only located in the habenular nucleus, while kiss2-expressing neurons are found in the dorsal and ventral hypothalamus.
The zebrafish kiss1 was expressed in brain, intestine, adipose tissue and testis.
Kiss1/Kiss1r (显示 KISS1R 蛋白) system may participate in puberty initiation in fish as well.
while uterine growth was fully rescued by E2 treatment of Kiss1(-/-) mice and by genetic restoration of kisspeptin signaling in GnRH (显示 GNRH1 蛋白) neurons in Kiss1r (显示 KISS1R 蛋白)(-/-) mice, functional adenogenesis was only marginally restored. Thus, while uterine growth is largely dependent on ovarian E2-output via central kisspeptin signaling, peripheral kisspeptin signaling is indispensable for endometrial adenogenesis and function
The findings are consistent with the idea that, during metabolic deficiency, AgRP (显示 AGRP 蛋白) signaling contributes to infertility by inhibiting Kiss1 neurons.
Study used Cre-lox (显示 LOX 蛋白) technology to selectively ablate tyrosine hydroxylase (TH (显示 TH 蛋白)) from Kiss1 cells. Surprisingly, despite a practically complete knock-out of TH from Kiss1 cells, study found that all aspects of puberty, reproductive hormone secretion, and fertility were normal in Kiss THKOs. This suggests that dopamine synthesized in Kiss1 cells is not required for normal puberty and reproduction.
Kisspeptin governs both mate preference and sexual motivation in female mice, indicating that sexual behavior and ovulation are coordinated by the same neuropeptide.
POMC (显示 POMC 蛋白) and AgRP (显示 AGRP 蛋白) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1(ARC (显示 NOL3 蛋白)) neurons in male mice
mice carrying Stat5a (显示 STAT5A 蛋白)/b inactivation specifically in kisspeptin cells were generated. These mutants exhibited an early onset of estrous cyclicity, indicating that STAT5 (显示 STAT5A 蛋白) transcription factors exert an inhibitory effect on the timing of puberty.
steroidal environment and energy state negatively regulate kisspeptin (Kiss1), neurokinin B (Tac2), and dynorphin (Pdyn (显示 PDYN 蛋白)) gene expression.
loss of PGR (显示 PGR 蛋白) impairs kisspeptin secretory machinery and therefore that PGR (显示 PGR 蛋白) plays a critical role in regulating kisspeptin secretion.
Neurons in the hypothalamus produce Kiss1 and can synchronize their activity and activate GnRH neurons thus coordinating reproduction and fertility.
Kisspeptin neuronal system plays an essential role as the gatekeeper of reproduction via stimulating GnRH secretion.(review)
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
, malignant melanoma metastasis-suppressor
, metastasis-suppressor KiSS-1
, kisspeptin 1
, Kiss1 metastasis-suppressor
, Kiss1 variant E1a-E2b-E3
, Kiss1 variant E1b-E2a-E3
, Kiss1 variant E1b-E2b-E3
, MLL septin-like fusion