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These results suggest that PAS-CPPs-GLP-2 is effective for i.n. delivery to the brain, and may be useful in the clinical treatment of major depression
Results suggest that GLP-2 (显示 GCG 蛋白) protected and improved memory function in LPS (显示 TLR4 蛋白)-treated mice, and also had anxiolytic effects due to changes in the 5-HT (显示 DDC 蛋白) system.
Report gastrointestinal GLP-2 receptor andl limited utility of GLP-2 in the management of inflammatory intestinal disorders.
GLP-2 (显示 GCG 蛋白) plays a key physiological role in the control of hepatic glucose production through activating PI3K-dependent modulation of membrane excitability and nuclear transcription of POMC (显示 POMC 蛋白) neurons in the brain.
Data suggest a role for endogenous GLP2 (glucagon-like peptide-2 (显示 GCG 蛋白)) and GLP2R in adaptation of mucosa of duodenum and jejunum to high-fat diet; results suggest dysregulation of GLP2/GLP2R signaling in obesity due to prolonged high-fat diet.
The data indicated that CNS GLP-2 receptor plays a physiological role in the control of feeding behavior and gastric emptying and that this is mediated probably through the melanocortin system.
Data suggest that the Vip (显示 Vip 蛋白) gene is not required for induction of a gene expression program linked to small bowel growth after enhancement of GLP-2 receptor signaling.
Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis
Data show that the GLP-2R is expressed by inhibitory and excitatory neurons, and inhibits the muscle contractility likely by decreasing cholinergic neurotransmission and increasing nitric oxide production.
GLP-2R is not critical for the stimulation/suppression of glucagon (显示 GCG 蛋白) secretion or glucose homeostasis in normal or lean diabetic mice. In obese mice GLP-2R signaling mediates the normal islet adaptive response required to maintain glucose homeostasis.
GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCzeta (显示 PRKCZ 蛋白) expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.
GLP-2 (显示 GCG 蛋白) augmented BRIN BD11 (显示 DEFB110 蛋白) beta-cell proliferation, but was less efficacious in 1.1B4 cells. These data highlight the involvement of GLP-2 receptor signalling in the adaptations to pancreatic islet cell stress.
This is the first time that human Epicardial adipose tissue is found to express both GLP-1R (显示 GLP1R 蛋白) and GLP-2R genes.
Report gastrointestinal GLP-2 receptor and limited utility of GLP-2 in the management of inflammatory intestinal disorders.
GLP-2 receptors are highly expressed in gastrointestinal stromal tumors and Crohn's disease.
GLP2R encodes a G protein-coupled receptor (显示 ADRA1A 蛋白) and involved in proliferative and anti-apoptotic cellular responses.
docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone
glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways
GLP-2 (显示 GCG 蛋白) in the gut (显示 GUSB 蛋白) acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth
GLP-2 receptor C terminus has a role in modulating beta-arrestin-2 association but not ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation
data demonstrate that cattle express proglucagon (显示 GCG 蛋白) and glucagon-like peptide 2 receptor mRNA primarily in small intestinal and colon tissues
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).
glucagon-like peptide 2 receptor
, G protein-coupled receptor GLP2R
, GLP-2 receptor
, glucagon-like peptide-2 receptor