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These results suggest that PAS-CPPs-GLP-2 is effective for i.n. delivery to the brain, and may be useful in the clinical treatment of major depression
Results suggest that GLP-2 protected and improved memory function in LPS-treated mice, and also had anxiolytic effects due to changes in the 5-HT system.
Report gastrointestinal GLP-2 receptor andl limited utility of GLP-2 in the management of inflammatory intestinal disorders.
GLP-2 plays a key physiological role in the control of hepatic glucose production through activating PI3K-dependent modulation of membrane excitability and nuclear transcription of POMC neurons in the brain.
Data suggest a role for endogenous GLP2 (glucagon-like peptide-2) and GLP2R in adaptation of mucosa of duodenum and jejunum to high-fat diet; results suggest dysregulation of GLP2/GLP2R signaling in obesity due to prolonged high-fat diet.
The data indicated that CNS GLP-2 receptor plays a physiological role in the control of feeding behavior and gastric emptying and that this is mediated probably through the melanocortin system.
Data suggest that the Vip gene is not required for induction of a gene expression program linked to small bowel growth after enhancement of GLP-2 receptor signaling.
Disruption of the murine Glp2r impairs Paneth cell function and increases susceptibility to small bowel enteritis
Data show that the GLP-2R is expressed by inhibitory and excitatory neurons, and inhibits the muscle contractility likely by decreasing cholinergic neurotransmission and increasing nitric oxide production.
GLP-2R is not critical for the stimulation/suppression of glucagon secretion or glucose homeostasis in normal or lean diabetic mice. In obese mice GLP-2R signaling mediates the normal islet adaptive response required to maintain glucose homeostasis.
Glucagon-like peptide-2 potentiates L-type voltage-gated Ca(2+) channels activity through activating cAMP-dependent protein kinase A signaling, partially stimulating glucose uptake by primary cultured hippocampal neurons.
Glp2r and ErbB pathways as essential components of the signaling network regulating the adaptive mucosal response to refeeding in the mouse intestine.
GLP-2 in the gut acts by activating receptors on the subepithelial myofibroblasts, causing the release of growth factors, which in turn stimulate intestinal growth
GLP2R expression was significantly increased in gastric chief cells in OB and OWD patients. PKCzeta expression was also significantly increased. This is the first evidence of increased GLP2R expression in chief cells of patients with severe obesity regardless of diabetes status.
GLP-2 augmented BRIN BD11 beta-cell proliferation, but was less efficacious in 1.1B4 cells. These data highlight the involvement of GLP-2 receptor signalling in the adaptations to pancreatic islet cell stress.
This is the first time that human Epicardial adipose tissue is found to express both GLP-1R and GLP-2R genes.
Report gastrointestinal GLP-2 receptor and limited utility of GLP-2 in the management of inflammatory intestinal disorders.
GLP-2 receptors are highly expressed in gastrointestinal stromal tumors and Crohn's disease.
GLP2R encodes a G protein-coupled receptor and involved in proliferative and anti-apoptotic cellular responses.
docking studies were performed between the N-terminal extracellular domain of GLP-2 receptor and the GLP-2 hormone
glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways
GLP-2 receptor C terminus has a role in modulating beta-arrestin-2 association but not ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation
GLP-2-induced stimulation of blood flow is mediated by vasoactive neurotransmitters that are colocalized with GLP-2R in 2 functionally distinct cell types within the gastrointestinal tract
Endogenously expressing GLP-2 receptor encoding mRNA and protein was identified in intestinal cell lines.
Sustained direct or indirect modulation of GLP-2R signaling does not modify intestinal tumor cell growth or survival.
data demonstrate that cattle express proglucagon and glucagon-like peptide 2 receptor mRNA primarily in small intestinal and colon tissues
The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).
glucagon-like peptide 2 receptor
, G protein-coupled receptor GLP2R
, GLP-2 receptor
, glucagon-like peptide-2 receptor