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Human Polyclonal FFAR1 Primary Antibody for ELISA, WB - ABIN250421
Hardy, St-Onge, Joly, Langelier, Prentki: Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. in The Journal of biological chemistry 2005
Cow (Bovine) Polyclonal FFAR1 Primary Antibody for WB - ABIN2792205
Sum, Tikhonova, Neumann, Engel, Raaka, Costanzi, Gershengorn: Identification of residues important for agonist recognition and activation in GPR40. in The Journal of biological chemistry 2007
Data indicate that 20-HETE and FFAR1 function together in a positive feedback loop to enhance glucose-stimulated insulin (显示 INS 抗体) secretion (GSIS).
Comparison with an additional 2.2-A structure of the human GPR40-MK-8666 binary complex reveals an induced-fit conformational coupling between the partial agonist and AgoPAM binding sites, involving rearrangements of the transmembrane helices 4 and 5 (TM4 (显示 TPM4 抗体) and TM5) and transition of the intracellular loop 2 (ICL2) into a short helix.
Results show that GPR40 negatively regulated the cell motile and invasive activities of HT1080 (显示 CDC123 抗体) cells suggesting that GPR40 negatively regulates the tumor progression of fibrosarcoma cells.
Brain free long-chain fatty acids-GPR40/FFA1 signaling might have an important role in the modulation of endogenous pain control systems. (review)
It regulates insulin (显示 INS 抗体) secretion in pancreatic beta-cells. (review)
Data from molecular docking simulations suggest that the binding pocket of GPR40 exhibits binding of free fatty acids (FFA) with chain lengths of C15 or fewer; for FFA with lengths longer than C15, part of alkyl chain extends out of binding pocket.
GPR120 (显示 O3FAR1 抗体) negatively and GPR40 positively regulate cellular functions during tumor progression in lung cancer cells.
Increased membrane permeability induced by linoleic acid is mediated by an intracellular signaling pathway activated by GPR40 that leads to an increase in membrane levels of Cx43 (显示 GJA1 抗体) phosphorylated at serine 373 via Akt (显示 AKT1 抗体).
These data demonstrate that R104 in GPR40 is critically involved in the normal receptor functions. Interestingly, R104P is a registered single-nucleotide polymorphism of GPR40.
Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120 (显示 O3FAR1 抗体)/FFA4
We found that FFAR1-/- female mice showed significant impairments in maternal behavior, and exhibited an emotionally altered behavior, when compared to WT mice. Our findings suggest that the dysfunction of brain PUFA-GPR40/FFAR1 signaling might induce damage to emotional and maternal behavior in female mice.
GPR120 (显示 O3FAR1 抗体) suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy
GPR40 and (GPR120 (显示 O3FAR1 抗体)) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity.
GPR40 role in the bone loss
These findings suggested that dysfunction of the GPR40/FFAR1 signaling pathway altered the endogenous pain control system and that this dysfunction might be associated with the development of chronic pain.
Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 partial agonist treatment with additional potential for weight loss.
These results support the hypothesis that mercaptoacetate stimulates food intake by blocking fatty acid effects on GPR40.
These results indicated that GPR120 (显示 O3FAR1 抗体) enhanced and GPR40 inhibited the cell motile activity of highly migratory osteosarcoma cells.
Results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain.
Data revealed a weak influence of GPR40 agonist on osteoblast markers expression. Nevertheless, a significant increase in OPG (显示 TNFSF11 抗体) expression was observed upon GW9508 treatment that contribute to explain the GPR40-related osteoporosis prevention
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes.
free fatty acid receptor 1
, G protein-coupled receptor 40
, G-protein coupled receptor 40
, G protein-coupled receptor GPR40