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Human Monoclonal HIP1 Primary Antibody for ChIP, ICC - ABIN152544
Rao, Hyun, Kumar, Mizukami, Rubin, Lucas, Sanda, Ross: Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. in The Journal of clinical investigation 2002
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Bacteria Monoclonal HIP1 Primary Antibody for ICC, IF - ABIN152545
Rao, Chang, Kumar, Mizukami, Smithson, Bradley, Parlow, Ross: Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. in Molecular and cellular biology 2001
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Human Monoclonal HIP1 Primary Antibody for IHC (p), IP - ABIN561263
Hibbert, Pflanz, De Waal Malefyt, Kastelein: IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003
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Human Polyclonal HIP1 Primary Antibody for ELISA, WB - ABIN561262
Hwang, Hong, Glimcher: IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. in The Journal of experimental medicine 2005
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Monoclonal HIP1 Primary Antibody for WB - ABIN534063
Mills, Gaughan, Robson, Ross, McCracken, Kelly, Neal: Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. in The Journal of cell biology 2005
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Human Polyclonal HIP1 Primary Antibody for ICC, IF - ABIN4317501
Majeed, Vasudevan, Chen, Luo, Torres, Evans, Sharkey, Foraker, Wong, Esk, Freeman, Moffett, Keen, Brodsky: Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. in Nature communications 2014
Huntingtin-interacting protein 1 (Hip1) functions in Notch (显示 NOTCH1 抗体)-mediated neurogenesis and provides a functional link between Notch (显示 NOTCH1 抗体) signaling and proteins related to Huntington disease (显示 HTT 抗体).
Data suggest that GLP1R (显示 GLP1R 抗体) signaling in pancreatic beta-cells leading to insulin (显示 INS 抗体) secretion involves interactions of GLP1R (显示 GLP1R 抗体) with HIP1, SNX1 (显示 SNX1 抗体), and SNX27 (显示 SNX27 抗体); HIP1 appears to regulate coupling of cell surface GLP1R (显示 GLP1R 抗体) activation with endocytosis; SNX1 (显示 SNX1 抗体) and SNX27 (显示 SNX27 抗体) appear to control balance between GLP1R (显示 GLP1R 抗体) plasma membrane recycling and lysosomal degradation.
HIP1 deletion is not involved in Williams-Beuren syndrome.
Huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis. metastasis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201412-2226OC#.V8DF69LrtNs
SHON is a novel human oncogene (显示 RAB1A 抗体) with predictive utility in ER(+) breast cancer, perhaps offering a simple biomarker to predict the therapeutic efficacy of antiestrogen therapy in patients with breast cancer.
SHON plays an important role in EMT (显示 ITK 抗体) and contributes to breast cancer progression.
HIP1-ALK, a novel fusion protein is associated with lung adenocarcinoma.
HIP1-ALK-rearranged tumor is sensitive to treatment with crizotinib, implicating HIP1-ALKas an oncogenic driver of lung tumorigenesis
Identified a four-tyrosine "HIP1 phosphorylation motif" in (显示 EGFR 抗体) the N-terminal region of HIP1 that is required for phosphorylation mediated by both EGFR and PDGFbetaR but not by the oncoproteins HIP1/PDGFbetaR (H/P), and TEL/PDGFbetaR (T/P).
Three neuronal proteins (Huntingtin interacting protein 1, neurofascin (显示 NFASC 抗体), and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent (显示 SFRP5 抗体) formation.
flexibility of the HIP1 coiled-coil domain is important for normal function and may lead to new insights into Huntington's disease
we show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase (显示 SERHL 抗体), Hip1.
HIP1 association with and phosphorylation mediated by EGFR (显示 EGFR 抗体) and EGFRvIII.
Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit (显示 KIT 抗体)
Results show that pro-apoptotic Hippi (显示 IFT57 抗体)-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi (显示 IFT57 抗体), Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathw
HIP1 is the first endocytic protein to be directly implicated in tumor formation
disuprtion results in neurological deficits and decreased AMPA (显示 GRIA3 抗体) receptor trafficking
mice deficient in both HIP1 and HIP1r (显示 HIP1R 抗体) have accelerated development of abnormalities seen in Hip1 -deficient mice, including kypholordosis and growth defects
The various abnormalities corroborate reduced fertility levels in HIP1(-/-) mice and suggest a role for HIP1 in stabilizing actin and microtubules, enabling normal spermatid and Sertoli cell morphology and function.
we have shown that HIP1 influences important NMDAR (显示 GRIN1 抗体) functions and that both HIP1 and htt (显示 HTT 抗体) participate in NMDA-induced cell death.
Degenerative phenotypes seen in knockout mice are due mainly to HIP1 and HIP1r (显示 HIP1R 抗体) protein deficiency rather than altered expression of neighboring genes or disrupted intronic elements.
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
, huntingtin interacting protein 1
, huntingtin-interacting protein 1
, huntingtin-interacting protein I