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AIF (显示 AIFM1 蛋白)-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls
Upregulated expression of AIFM3 is associated with cholangiocarcinoma.
The expression of apoptosis-inducing factor (显示 AIFM1 蛋白) was identified in pineal gland and thymus, but it did not change with age.
AIFM3 is a direct target of miR (显示 MLXIP 蛋白)-210 in human hepatoma cells.
AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase (显示 TXNRD1 蛋白) domain (Pyr_redox). AIFL shares 35% homology with AIF (显示 AIFM1 蛋白), mainly in the Pyr_redox domain.
AIF (显示 AIFM1 蛋白) maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function.
H. pylori triggers apoptosis in AGS (显示 JAG1 蛋白) cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c (显示 CYCS 蛋白) and AIF (显示 AIFM1 蛋白) from mitochondria, and activation of subsequent downstream apoptotic events
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity).
apoptosis-inducing factor, mitochondrion-associated, 3
, neurula-specific ferredoxin reductase-like protein
, novel protein similar to vertebrate apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3)
, apoptosis-inducing factor 3-like
, apoptosis-inducing factor 3
, apoptosis-inducing factor like
, apoptosis-inducing factor-like protein
, apoptosis-inducing factor, mitochondrion-associated 3