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抗Mouse (Murine) PPP2R2B 抗体:
抗Human PPP2R2B 抗体:
抗Rat (Rattus) PPP2R2B 抗体:
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
New pathogenic threshold of PPP2R2B CAG-43 to be pathogenic for SCA12 diagnosis.
CAG triplet repeat expansion has been found in untranslated region of SCA12 gene in Indian spinocerebellar ataxia 12 patients.
Thus, Fcp1 (显示 CTDP1 抗体) coordinates Cdk1 (显示 CDK1 抗体) and Gwl (显示 MASTL 抗体) inactivation to derepress PP2A (显示 PPP2R4 抗体)-B55 (显示 MINK1 抗体), generating a dephosphorylation switch that drives mitosis progression.
investigated CAG copies within PPP2R2B in 29 patients with spinocerebellar ataxia who are excluded from the most common subtypes; 3 patients carried 53, 46 and 54 CAG repeats respectively, while the other 26 cases harbored CAG repeats less than 30
IER5 (显示 IER5 抗体) functions as a positive feedback regulator of HSF1 (显示 HSF1 抗体) and that this process involves PP2A (显示 PPP2R4 抗体)/B55 (显示 MINK1 抗体) and HSF1 (显示 HSF1 抗体) dephosphorylation.
Bcl-2 (显示 BCL2 抗体) phosphorylation at Ser70 by selective tyrosine nitration of PP2A (显示 PPP2R4 抗体)-B56delta stabilizes its antiapoptotic activity
Inactivation of protein-phosphatase 2A causing hyperphosphorylation of paraprotein targets in monoclonal gammopathy of undetermined significance, multiple myeloma and Waldenstrom's macroglobulinemia is due to an exchange of its regulatory subunits
Identification of the adenovirus E4orf4 protein binding site on the B55alpha (显示 PPP2R2A 抗体) and Cdc55 regulatory subunits of PP2A (显示 PPP2R4 抗体): Implications for PP2A (显示 PPP2R4 抗体)
We demonstrate that PP2A/B55 is required for Gwl dephosphorylation at the essential Cdk site Thr194. Ensa/ARPP19 dephosphorylation is mediated by the RNA
PP2A (显示 PPP2R4 抗体)-B55beta promotes cyclin E1 (显示 CCNE1 抗体) overexpression by antagonizing its degradation and its inhibition could represent a therapeutic mechanism for abrogating cyclin E1 (显示 CCNE1 抗体) function in cancers
TRPV1 (显示 TRPV1 抗体) activation in endothelial cells may elicit a Ca(2 (显示 CA2 抗体)+) -dependent effect on PP2B-PKC (显示 PKC 抗体) signalling, which leads to dephosphorylation of eNOS (显示 NOS3 抗体)
The protein phosphatase PP2A/Balpha binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn (显示 FYN 抗体).
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling.
equilibrium between CDK1 (显示 CDK1 抗体) and PP2A specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.
inhibition of PP2A-B55delta results from Ensa (显示 ENSA 抗体), that is phosphorylated in mitosis by the protein kinase (显示 CSNK1D 抗体) Greatwall (显示 MASTL 抗体); this converts Ensa (显示 ENSA 抗体) into specific inhibitor of PP2A-B55delta; this pathway represents a previously unknown element in mitosis control
study describes how Gwl (显示 MASTL 抗体) activation results in PP2A inhibition; identified Arpp19 (显示 ARPP19 抗体) and alpha-Endosulfine (显示 ENSA 抗体) that, when phosphorylated by Gwl (显示 MASTL 抗体), associate with and inhibit PP2A promoting mitotic entry
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
, beta isoform of regulatory subunit B55, protein phosphatase 2
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform
, PP2A subunit B isoform B55-beta
, PP2A subunit B isoform PR55-beta
, PP2A subunit B isoform R2-beta
, PP2A subunit B isoform beta
, PP2A, subunit B, B-beta isoform
, PP2A, subunit B, B55-beta isoform
, PP2A, subunit B, PR55-beta isoform
, PP2A, subunit B, R2-beta isoform
, protein phosphatase-2A subunit-beta
, protein phosphatase 2, regulatory subunit B, beta
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like
, serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform
, serine/threonine protein phosphatase 2A, neuronal isoform
, BRbeta B-regulatory subunit of protein phosphatase 2A
, PP2A subunit B isoform BRB
, PP2A, subunit B, BRB isoform
, protein phosphatase 2A 55 kDa regulatory subunit, beta isoform
, phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform