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PIP5K1A 抗体

(Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
PIP5K1A 抗体  (AA 1-500) PIP5K1A 抗体  (AA 1-500) PIP5K1A 抗体 (AA 1-500) (ABIN948678)

PIP5K1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

PIP5K1A 抗体  (AA 293-562) PIP5K1A 抗体  (AA 293-562) PIP5K1A 抗体 (AA 293-562) (ABIN7163185)

PIP5K1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

PIP5K1A 抗体  (N-Term) PIP5K1A 抗体  (N-Term) PIP5K1A 抗体 (N-Term) (ABIN6264231)

PIP5K1A 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

PIP5K1A 抗体 by Grade

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PIP5K1A 抗体 by 适用

Find PIP5K1A 抗体 for a variety of species such as anti-Human PIP5K1A, anti-Rat PIP5K1A, anti-Mouse PIP5K1A. The species listed below are among those available. Click on a link to go to the corresponding products.

PIP5K1A 抗体 by 应用范围

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PIP5K1A 抗体 by 克隆形成能力

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PIP5K1A 抗体 by 克隆

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PIP5K1A 抗体 by 标记

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Popular PIP5K1A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN948678
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7163185
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (2)
Cat. No. ABIN6264231
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
  • (2)
Cat. No. ABIN392593
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Rat
Application IF
Validations
  • (1)
Cat. No. ABIN7008201
Quantity 60 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN563607
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC, IF
Validations
Cat. No. ABIN7117417
Quantity 100 μg
Datasheet Datasheet

Application WB
Validations
Cat. No. ABIN6752744
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IP
Validations
Cat. No. ABIN7135674
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN1805304
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
Cat. No. ABIN7269295
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN2583859
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, ICC, IHC (p)
Validations
Cat. No. ABIN7466571
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN1924161
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN1924162
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our PIP5K1A 抗体

Bolomini-Vittori, Montresor, Giagulli, Staunton, Rossi, Martinello, Constantin, Laudanna: "Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module." in: Nature immunology, Vol. 10, Issue 2, pp. 185-94, (2009) (PubMed).

Zhu, Zeisel: "Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice." in: Brain research. Molecular brain research, Vol. 134, Issue 2, pp. 239-55, (2005) (PubMed).

Doughman, Firestone, Wojtasiak, Bunce, Anderson: "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling." in: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 23036-45, (2003) (PubMed).

Xie, Zhu, Zhao: "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 88, Issue 3-4, pp. 197-9, (2000) (PubMed).

Aliases for PIP5K1A 抗体

phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A) 抗体
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a) 抗体
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L) 抗体
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a) 抗体
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a) 抗体
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa) 抗体
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a) 抗体
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab) 抗体
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