anti-人 MTOR 抗体 for Dot Blot

Recommended MTOR Antibody (supplied by: Log in to see )

抗原
Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) 抗体
  • FRAP1
  • FRAP
  • FRAP2
  • RAFT1
  • RAPT1
  • 2610315D21Rik
  • AI327068
  • Frap1
  • flat
  • frap1
  • tor
  • wu:fc22h08
  • mechanistic target of rapamycin kinase
  • mechanistic target of rapamycin
  • mechanistic target of rapamycin (serine/threonine kinase)
  • MTOR
  • Mtor
  • mtor
抗原表位
pThr2446
64
36
27
21
21
15
15
13
12
10
8
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
适用

370
196
193
18
9
8
7
7
7
7
4
4
2
1
1
宿主

318
48
3
1
克隆类型
多克隆
标记
This MTOR antibody is un-conjugated
8
8
7
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
应用范围
Dot Blot (DB)
251
111
99
73
54
52
36
20
8
7
7
6
3
2
2
2
1
1
1
选项
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产品编号 ABIN1881353
$ 324.50
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2794213 DB Rabbit Ig Fraction pThr2446 Log in to see Polyclonal

General

抗原 Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) 抗体
抗原表位 pThr2446
(64), (36), (27), (21), (21), (15), (15), (13), (12), (10), (8), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用
(370), (196), (193), (18), (9), (8), (7), (7), (7), (7), (4), (4), (2), (1), (1)
宿主
(318), (48), (3), (1)
克隆类型 (克隆位点)
多克隆   ( )
标记 This MTOR antibody is un-conjugated
(8), (8), (7), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3)
应用范围 Dot Blot (DB)
(251), (111), (99), (73), (54), (52), (36), (20), (8), (7), (7), (6), (3), (2), (2), (2), (1), (1), (1)
Pubmed 4个引用可参考
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MTOR抗体详情

MTOR目标详情 使用细节 贮存及处理 References for anti-MTOR antibody (ABIN1881353) 图像
预测反应 Mouse (Murine),Rat (Rattus)
纯化方法 This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
免疫原 This FRAP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T2446 of human FRAP1.
克隆位点 RB13089

MTOR目标详情

MTOR抗体详情 使用细节 贮存及处理 References for anti-MTOR antibody (ABIN1881353) 图像 回页首
抗原
别名 FRAP1 (FRAP1 Antibody 摘要)
背景 FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Synonyms: MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, Serine/threonine-protein kinase mTOR, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1
NCBI登录号 NP_004949
UniProt P42345
途径 PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events

使用细节

MTOR抗体详情 MTOR目标详情 贮存及处理 References for anti-MTOR antibody (ABIN1881353) 图像 回页首
应用备注 DB: 1:500
限制 仅限研究用

贮存及处理

MTOR抗体详情 MTOR目标详情 使用细节 References for anti-MTOR antibody (ABIN1881353) 图像 回页首
状态 Liquid
浓度 0.45 mg/mL
缓冲液 Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
储存液 Sodium azide
注意事项 WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-MTOR antibody (ABIN1881353)

MTOR抗体详情 MTOR目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Pillai, Sundaresan, Kim, Gupta, Rajamohan, Pillai, Samant, Ravindra, Isbatan, Gupta: "Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 3133-44, 2010

Dowling, Zakikhani, Fantus, Pollak, Sonenberg: "Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells." in: Cancer research, Vol. 67, Issue 22, pp. 10804-12, 2007

Bai, Ma, Liu, Shen, Wang, Liu, Jiang: "Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38." in: Science (New York, N.Y.), Vol. 318, Issue 5852, pp. 977-80, 2007

Zhou, Wulfkuhle, Zhang, Gu, Yang, Deng, Margolick, Liotta, Petricoin, Zhang: "Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 41, pp. 16158-63, 2007

图像

MTOR抗体详情 MTOR目标详情 使用细节 贮存及处理 References for anti-MTOR antibody (ABIN1881353) 回页首
厂商提供的图像
Dot Blot (DB) image for anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pThr2446) antibody (ABIN1881353) Dot blot analysis of anti-FRAP1-pT2446 Phospho-specific Pab (Cat.AP3433a) on nitrocel...