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抗Human MTOR 抗体:
抗Mouse (Murine) MTOR 抗体:
抗Rat (Rattus) MTOR 抗体:
Human Polyclonal MTOR Primary Antibody for IF (p), IHC (p) - ABIN676403
Li, Liu, Wang, Sun, Ding, Sun, Han, Wang: Follistatin could promote the proliferation of duck primary myoblasts by activating PI3K/Akt/mTOR signalling. in Bioscience reports 2014
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Human Polyclonal MTOR Primary Antibody for ELISA, EM - ABIN153493
Gupta, Dillon, Ziesmer, Feldman, Witzig, Ansell, Cerhan, Novak: A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. in Blood 2009
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Human Polyclonal MTOR Primary Antibody for ICC, IF - ABIN151707
Bolster, Vary, Kimball, Jefferson: Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. in The Journal of nutrition 2004
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Human Polyclonal MTOR Primary Antibody for DB - ABIN1881353
Dowling, Zakikhani, Fantus, Pollak, Sonenberg: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. in Cancer research 2007
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Human Polyclonal MTOR Primary Antibody for IHC (p), WB - ABIN272127
Li, Yan, Zhang, Jiang, Sun, Hu, Sun, Xu: miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6. in FEBS letters 2013
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Human MTOR Primary Antibody for IHC - ABIN966602
Holz, Blenis: Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. in The Journal of biological chemistry 2005
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Human Polyclonal MTOR Primary Antibody for IF (p), IHC (p) - ABIN747158
Yang, Wang, Wang, Zhang, Zhang, Lu, Wang: mTOR is involved in 17?-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. in Molecular reproduction and development 2015
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Human Polyclonal MTOR Primary Antibody for IF, IHC - ABIN362262
Albanell, Dalmases, Rovira, Rojo: mTOR signalling in human cancer. in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2007
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Human Polyclonal MTOR Primary Antibody for IHC, ELISA - ABIN1531910
Luo, Yoneda, Ohmori, Sasaki, Shimbo, Eto, Kato, Miyano, Kobayashi, Sasahira, Chihara, Kuniyasu: Cancer usurps skeletal muscle as an energy repository. in Cancer research 2014
Human Polyclonal MTOR Primary Antibody for IF, IHC (p) - ABIN390217
Cao, Dong, Meng, Liu, Liao, Liu: MiR-511 inhibits growth and metastasis of human hepatocellular carcinoma cells by targeting PIK3R3. in Tumour biology 2015
High mTOR expression is associated with gastric cancer.
The authors demonstrate that, particularly when autophagy is upregulated, varicella-zoster virus inhibits mTOR-mediated late-stage autophagic flux, likely at the point where autophagosomes and lysosomes fuse or where vesicle contents are degraded. Importantly, inhibition of autophagy yields higher varicella-zoster virus titers.
Identification of a functional mTOR targeted multigene signature robustly discriminates between normal prostate tissues, primary tumors, and hormone refractory metastatic samples but is also predictive of cancer recurrence
2-ME reduced the production of CTGF (显示 CTGF 抗体) and collagen I in SSc (显示 CYP11A1 抗体) fibroblasts induced by hypoxia through PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体)/mTOR/HIF-1alpha (显示 HIF1A 抗体) signalling and inhibited the proliferation of fibroblasts. These findings suggested that 2-ME could be employed as a promising antifibrotic therapy for SSc (显示 CYP11A1 抗体)
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (显示 INS 抗体) activates mTORC2 (显示 CRTC2 抗体) remains poorly defined.
miR33a5p inhibited the proliferation of lung adenocarcinoma cells, enhanced the antitumor effect of celastrol, and improved sensitivity to celastrol by targeting mTOR in lung adenocarcinoma in vitro and in vivo
miR (显示 MLXIP 抗体)-181 may be a novel and important regulator of cisplatin-resistant non-small cell lung cancer by serving a role in the regulation of apoptosis, as an established rate-limiting miRNA target.
Evaluation of the potential mechanism demonstrated that TRIM28 (显示 TRIM28 抗体) promoted cervical cancer cell growth by activating the mammalian target of rapamycin (mTOR) signaling pathway. In support of this finding, TRIM28 (显示 TRIM28 抗体)-induced cell proliferation was abolished by treatment with everolimus, a specific mTOR inhibitor
MiR (显示 MLXIP 抗体)-101 and mTOR expressions significantly declined in endometrial cancer (EC) tissue.
while mTOR inhibitors restore endocrine sensitivity, CDK4/6 (显示 CDK4 抗体) inhibitors may favor the emergence of estrogen receptor 1 (ESR1 (显示 ESR1 抗体)) mutations resulting in ligand-independent activity of the receptor
The control of cMaf (显示 MAF 抗体) expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge.
The function of mTOR in epidermal morphogenesis is split between mTORC1 and mTORC2 (显示 CRTC2 抗体). Whereas mTORC1 mainly controls keratinocyte proliferation within the basal layer, early epidermal stratification and differentiation, mTORC2 (显示 CRTC2 抗体) primarily controls cell division orientation and late stage barrier formation of the interfollicular epidermis.
Loss of mTOR in vasoactive intestinal peptide (显示 Vip 抗体) neurons displayed erratic circadian behavior and weakened synchronization among cells in the suprachiasmatic nucleus, the master circadian pacemaker.
T1R1 (显示 TAS1R1 抗体)/T1R3 (显示 TAS1R3 抗体) modulates the mTOR pathway to regulate milk protein synthesis in the mouse mammary gland in vivo.
the protein expression levels of mTOR were significantly reduced in spinal cord injury (SCI) neurons, whereas transfection with a miR99b5p inhibitor suppressed the SCIinduced reduction of mTOR.
Adoptive transfer with targeting-mTOR strategy markedly improves neuronal recovery after ONI, supporting the therapeutic potentials of Tregs in acute and chronic neurological disorder
Activation of the mTOR pathway was partially repressed by T1R1 (显示 TAS1R1 抗体) siRNA or SLC7A5 (显示 SLC7A5 抗体)/SLC3A2 (显示 SLC3A2 抗体) inhibitor (BCH (显示 CHN2 抗体), 10 mM), and the combination of these two treatments further repressed the activity of mTOR pathway.
Ggpps (显示 GGPS1 抗体) deletion enhanced Rheb (显示 RHEB 抗体) farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation
mTOR is crucial for T-cell accumulation in the GI tract and for establishing local adaptive immunity against pathogens.
Data show that mammalian/mechanistic target of rapamycin (mTOR) perturbation alters the suprachiasmatic nucleus (SCN (显示 SRI 抗体)) clock oscillations.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (显示 ESCO2 抗体) cells and supports that normal gene expression and translation requires ESCO2 (显示 ESCO2 抗体) function.
By inhibiting mTOR signaling via Fbxw7 (显示 FBXW7 抗体), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (显示 TP53 抗体).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (显示 PPARG 抗体). In summary, PPARg (显示 PPARG 抗体) plays an important role in the regulation of IGF-1 (显示 IGF1 抗体) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (显示 AKT1 抗体)-mTOR-FOXO1 (显示 FOXO1 抗体) signaling and suppressing the activation of TLR4 (显示 TLR4 抗体) and/or NOD2 (显示 NOD2 抗体) signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (显示 PRKAA1 抗体)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (显示 GUCA2B 抗体) modulates (Na++K+)ATPase (显示 ATP1A1 抗体) in a proximal tubule cells via cGMP/protein kinase (显示 CDK7 抗体) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (显示 CCND1 抗体), and CCNE1 (显示 CCNE1 抗体).
L-Glutamine (显示 GFPT2 抗体) enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr (显示 PTCHD3 抗体) cells through activation of the MTOR-RPS6K-RPS6 (显示 RPS6 抗体)-EIF4EBP1 (显示 EIF4EBP1 抗体) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (显示 MAP1LC3A 抗体), B and autophagy-associated genes (ATG5 (显示 ATG5 抗体), mTOR, Beclin-1 (显示 BECN1 抗体)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (显示 GATM 抗体) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (显示 ANXA2 抗体) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (显示 SREBF1 抗体)/Cyclin D1 (显示 CCND1 抗体) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (显示 YWHAG 抗体) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (显示 JAK2 抗体)-STAT5 (显示 STAT5A 抗体) and mTOR signaling pathways.
Insulin (显示 INS 抗体)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (显示 IGF1 抗体) down-regulated functional IGF-I receptor (显示 IGF1R 抗体) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (显示 IGF1R 抗体) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (显示 INS 抗体), and prolactin (显示 PRL 抗体) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 (显示 TSC2 抗体) and activates mTOR and ribosomal protein S6 (显示 RPS6 抗体) kinase (显示 RPS6KB1 抗体) signaling in an AKT (显示 AKT1 抗体)-independent manner
mTOR links IGF-I (显示 IGF1 抗体) and EGF (显示 EGF 抗体) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin