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|抗原||DEP Domain Containing MTOR-Interacting Protein (DEPTOR) 抗体|
|抗原表位||AA 62-107 其他选择|
|适用||人, 小鼠 其他选择|
|标记||This DEPTOR antibody is un-conjugated 其他选择|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
DEPTOR抗体详情DEPTOR目标详情 使用细节 贮存及处理 References for anti-DEPTOR antibody (ABIN1387597) 图像
|纯化方法||Purified by Protein A.|
|免疫原||KLH conjugated synthetic peptide derived from human DEPTOR/DEPDC6|
DEPTOR目标详情DEPTOR抗体详情 使用细节 贮存及处理 References for anti-DEPTOR antibody (ABIN1387597) 图像 回页首
|别名||Deptor (DEPTOR Antibody 摘要)|
DEPTOR (DEP domain containing MTOR-interacting protein), also known as DEP.6 or DEPDC6 (DEP domain-containing protein 6), is a 409 amino acid protein that negatively regulates mTORC1 and mTORC2 pathways. DEPTOR interacts with FRAP via its PDZ domain, and undergoes post-translational phosphorylation. Containing two DEP domains and one PDZ (DHR) domain, DEPTOR is encoded by a gene that maps to human chromosome 8q24.12. Chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.
Synonyms: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6, DEPTOR
|途径||PI3K-Akt Signaling, RTK signaling, Regulation of Cell Size|
使用细节DEPTOR抗体详情 DEPTOR目标详情 贮存及处理 References for anti-DEPTOR antibody (ABIN1387597) 图像 回页首
贮存及处理DEPTOR抗体详情 DEPTOR目标详情 使用细节 References for anti-DEPTOR antibody (ABIN1387597) 图像 回页首
|缓冲液||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|储存方法||Store at -20°C|
References for anti-DEPTOR antibody (ABIN1387597)DEPTOR抗体详情 DEPTOR目标详情 使用细节 贮存及处理 图像 回页首
Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: "High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma." in: OncoTargets and therapy, Vol. 8, pp. 3449-55, 2015 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Human).
图像DEPTOR抗体详情 DEPTOR目标详情 使用细节 贮存及处理 References for anti-DEPTOR antibody (ABIN1387597) 回页首