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Human Cyclin A Protein expressed in Wheat germ - ABIN1348430
Touati, Cladière, Lister, Leontiou, Chambon, Rattani, Böttger, Stemmann, Nasmyth, Herbert, Wassmann: Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis. in Cell reports 2012
the presented evidence suggested that WA can inhibit HCC (显示 FAM126A 蛋白) cell proliferationand tumorigenesis through miR (显示 MLXIP 蛋白)-22-repressed CCNA2, which was at least partially through FXR (显示 NR1H4 蛋白) regulation
Findings suggest that ERK1/2-mediated Cdk2 (显示 CDK2 蛋白)/cyclin A signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
some cancer cells are defective for efficient interaction between p27 (显示 PAK2 蛋白) and CycA-CDK (显示 CDK4 蛋白) complex due to qualitative alteration(s)
This study shows that cocaine induces significant increases in both the astrocytic expression of cyclin A2 and the proliferation of primary human astrocytes.
Low CCNA expression is associated with lung cancer progression.
cyclin D1 (显示 CCND1 蛋白) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (显示 RAD51 蛋白) interaction with the BRCA2 (显示 BRCA2 蛋白) C-terminal domain
inhibition of PDK4 (显示 PDK4 蛋白) activity in Hepatocellular carcinoma cells increased cyclin E1 (显示 CCNE1 蛋白), cyclin A2, and E2F1 (显示 E2F1 蛋白) proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (显示 CDK2 蛋白) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (显示 WEE1 蛋白) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (显示 CDKN1A 蛋白), p27 (显示 PAK2 蛋白)-cyclin E (显示 CCNE1 蛋白),A/Cdk2 (显示 CDK2 蛋白) pathway.
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis (显示 AMH 蛋白)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 (显示 MRE11A 蛋白) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (显示 MRE11A 蛋白) transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR (显示 MLXIP 蛋白)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (显示 EEF2K 蛋白) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (显示 CTNNB1 蛋白) and phospholipase C (显示 PLC 蛋白) pathways.
Ccn2 (显示 CTGF 蛋白) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.
B-Myb (显示 MYBL2 蛋白) represses SMC (显示 DYM 蛋白) elastin (显示 ELN 蛋白) gene expression and cyclin A plays a role in the developmental regulation of elastin (显示 ELN 蛋白) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (显示 UHRF1 蛋白) phosphorylation by cyclin-dependent kinase 2 (显示 CDK2 蛋白)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)