CCCTC-Binding Factor (Zinc Finger Protein) (CTCF) Peptide
CTCF
适用: 人
宿主: 合成
BP, WB, ChIP
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- 抗原 See all CTCF products
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
- 宿主
- 人
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-CTCF antibody (Catalog #: ARP38820_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
- 别名
- im:7152666 Peptide, CTCF Peptide, xctcf Peptide, AW108038 Peptide, CCCTC-binding factor Peptide, CCCTC-binding factor (zinc finger protein) Peptide, CTCF Peptide, ctcf Peptide, Ctcf Peptide
- 背景
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CTCF is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.
Protein Interaction Partner: EIF2S3,THRB,YBX1,HMGB1,POLR2A,SMAD3,SMAD4,THRB,YBX1,CHD7,CHD8,SUZ12,YBX1
Protein Size: 727 - 分子量
- 83 kDa
- 基因ID
- 10664
- NCBI登录号
- NM_006565, NP_006556
- UniProt
- P49711
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