Cytokine Inducible SH2-Containing Protein (CISH) (N-Term) Peptide
CISH
适用: 小鼠
宿主: 合成
BP, WB
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- 抗原 See all CISH products
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- 蛋白结构域
- N-Term
- 宿主
- 小鼠
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资源
- 合成
- 应用范围
- Blocking Peptide (BP), Western Blotting (WB)
- 序列
- RESGWYWGSI TASEARQHLQ KMPEGTFLVR DSTHPSYLFT LSVKTTRGPT
- 产品特性
- This is a synthetic peptide designed for use in combination with anti-Cish Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- 纯化方法
- Purified
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- 应用备注
- Each Investigator should determine their own optimal working dilution for specific applications.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- 浓度
- 1 mg/mL
- 缓冲液
- Final peptide concentration is 1 mg/mL in PBS.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 抗原
- CISH (Cytokine Inducible SH2-Containing Protein (CISH))
- 别名
- CISH Peptide, cis Peptide, cish.a Peptide, ptk9l Peptide, twf1l Peptide, wu:fk57g04 Peptide, zgc:154062 Peptide, zgc:91817 Peptide, g18 Peptide, socs Peptide, cis-1 Peptide, cish Peptide, BACTS2 Peptide, CIS Peptide, CIS-1 Peptide, G18 Peptide, SOCS Peptide, AI385595 Peptide, CIS1 Peptide, Cis Peptide, F17 Peptide, F23 Peptide, cytokine inducible SH2 containing protein Peptide, cytokine inducible SH2-containing protein Peptide, CISH Peptide, cish Peptide, Cish Peptide
- 背景
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SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: AI385595, CIS1, Cis, F17, F23
Protein Interaction Partner: Stat5a
Protein Size: 257 - 分子量
- 28 kDa
- 基因ID
- 12700
- NCBI登录号
- NM_009895, NP_034025
- UniProt
- Q62225
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