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There was a significant increase in protein levels of ZnT6 in the prefrontal cortex in Major depression disorder, relative to control subjects.
A genetic variant within SLC30A6 has a protective role in the severity of Rheumatoid Arthritis.
results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients.
The results of this study showed that signi fi cant positive correlations between ZIP1 (显示 SLC39A1 蛋白),ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease.
our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 (显示 SLC30A4 蛋白) and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms
hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells.
Data show that ZNT6 is extensively present in the Abeta (显示 APP 蛋白)-positive plaques in the cortex of human AD brains.
The cytosolic C-terminal tail of ZnT5 (显示 SLC30A5 蛋白) is important for its interaction with ZnT6 as a heterodimer.
overexpression of ZnT6 causes growth inhibition, znT6 functions in zinc homeostasis and transport
Expression of zinc transporter ZnT6 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Increased ZnT-6 immunostaining in neurons containing cytoplasmic inclusions in MCI (显示 MCIN 蛋白), AD, and PD suggests a role for ZnT-6 in the pathogenesis of these lesions.
Our results revealed that ZNT7 (显示 SLC30A7 蛋白) immunoreactivity was abundantly expressed in the nerve cells of the mouse DRG.Double immunofluorescence labeling of ZNT7 (显示 SLC30A7 蛋白) and TGN38 (显示 TGOLN2 蛋白) revealed a colocalization of the two antigens in the Golgi apparatus.
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004
zinc transporter 6
, solute carrier family 30 member 6
, solute carrier family 30 (zinc transporter), member 4
, zinc transporter-like 3