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抗Human RAB27A 抗体:
抗Mouse (Murine) RAB27A 抗体:
抗Rat (Rattus) RAB27A 抗体:
Human Monoclonal RAB27A Primary Antibody for IHC (p), RNAi - ABIN562560
Kimura, Kaneko, Yamada, Ishihara, Senda, Iwamatsu, Niki: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines. in Journal of cell science 2008
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Human Polyclonal RAB27A Primary Antibody for WB - ABIN1881720
Ohbayashi, Mamishi, Ishibashi, Maruta, Pourakbari, Tamizifar, Mohammadpour, Fukuda, Parvaneh: Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2. in Pigment cell & melanoma research 2010
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Rat (Rattus) Polyclonal RAB27A Primary Antibody for IP, WB - ABIN1742354
Lovis, Roggli, Laybutt, Gattesco, Yang, Widmann, Abderrahmani, Regazzi: Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. in Diabetes 2008
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Rat (Rattus) Polyclonal RAB27A Primary Antibody for IP, WB - ABIN1742353
de Wit, Walter, Milosevic, Gulyás-Kovács, Riedel, Sørensen, Verhage: Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. in Cell 2009
These results collectively suggest that the active form of Rab27a enhances human parainfluenza virus type 2 growth by promoting transport of F and HN proteins to the plasma membrane.
A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism.
We reported the first patient with GS2 in Thailand. The patient was compound heterozygous for two novel mutations, c.109A>T (p.K37X) and c.318T>G (p.S106R). We reported the first case of a successful prenatal diagnosis for GS2. The result revealed that the fetus carried the p.K37X, but not the p.S106R (Fig. C), suggesting that the fetus would be unaffected with GS2.
Findings indicate that rab GTP-binding proteins Rab27A and Rab27B play significant roles in cell invasion, proliferation, and apoptosis, as well as in chemotherapy resistance.
Here, we report on a new RAB27A genetic anomaly observed in seven Saudi Arabia families that had remained negative after extensive molecular genomic DNA testing. Linkage analysis and targeted sequencing of the RAB27A genomic region in several of these patients led to the identification of a common homozygous tandem duplication of 38 kb affecting exon 2-5 and resulting in a premature stop codon
In comparison with the normal tissues, miR-182-5p is expressed at a higher level in gastric cancer (GC) tissues, while RAB27A is expressed at a lower level in cancerous tissues. The down-regulation of miR-182-5p and up-regulation of RAB27A can significantly decrease the viability, migration, invasion, and mitosis of HGC-27 cells.
Rab27A is mediated by NF-kappaB and promotes stemness of colon cancer cells via up-regulation of cytokine secretion
These results demonstrated that miR-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.
These signaling pathways can trigger several secretion modes including single WPB release and multigranular exocytosis. In this review we will give an overview of the WPB lifecycle from biogenesis to secretion and we will discuss several deficiencies that affect the WPB lifecycle. [review]
RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36.
identified small molecule inhibitors of Rab27a-JFC1 binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab GTPases and their effectors.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
decreased expression of Rab27A and Rab27B, especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).
Data suggest that microRNA miR-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC) by targeting RAS-related GTP-binding protein (Rab27a), indicating a novel therapeutic strategy for patients with CRC.
Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.
miR-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle
Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.
Our data indicate that RAB27A expression is an independent prognostic marker for pancreatic ductal adenocarcinoma
This study identified a common variant located in RAB27A gene influencing FeNO levels specifically in adults and with a biological relevance to the regulation of FeNO levels.
IRF-1 regulates Rab27a transcription and extracellular vesicles secretion, leading to oxidized phospholipids activation of neutrophils and subsequent hepatic ischemia reperfusion injury
miR-124 has an important role in osteoclastogenesis via targeting Rab27a.
this study shows that Rab27a and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF-dependent neutrophil priming is involved.
These results suggest that the dual effector, Noc2, regulates the transition from Rab2a-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Loss of Rab3D from secretory vesicles, leading to disproportionate Rab27-to-Rab3D activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
The Rab27A regulates CG exocytosis following MII-stage oocyte activation.
Given that GTP- and GDP-bound Rab27a regulate exocytosis.
This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 subunit of L-type channels, leading to decreased current density and reduced VEGF-A secretion by the retinal pigment epithelium.
results show that Rab27A is present in mouse pancreatic acinar cells and mainly regulates secretion through the minor-regulated pathway
Rab27A deficiency shows the increased surface level of c-fms, and the delayed downregulation of RANK in ashen cells, resulting in enhanced signaling of M-CSF and RANKL.
Rab27b is expressed in bone marrow derived neutrophils and Rab27b knockout (Rab27b KO) along with Rab27a/b double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 and LTB4.
Our findings indicate that Slp2-a controls renal cell size through regulation of Rap-ezrin signaling independently of Rab27.
The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin.
Rab27a has a key role in eosinophil degranulation. Furthermore, these findings have implications for Rab27a-dependent eosinophil degranulation in airway inflammation.
Upregulation of the Rab27a-dependent lysosomal trafficking and secretory pathways contributes to the correction of some of the cellular defects induced by lysosomal overload in cystinosis, including endoplasmic reticulum stress.
Data suggest that Rab27a and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a/Mlph/MyoVa regulating cortical actin stability upstream of Rab27a/b/Munc13-4-dependent granule exocytosis.
Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RAB27A, member RAS oncogene family
, Ras-related protein Rab-27A
, rab27a, member ras oncogene family
, ras-related protein Rab-27A
, GTP-binding protein Ram
, member RAS oncogene family, RAB27A
, low Mr GTP-binding protein
, ram p25
, RAS oncogene family member