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Human Monoclonal RAB27A Primary Antibody for IHC (p), RNAi - ABIN562560
Kimura, Kaneko, Yamada, Ishihara, Senda, Iwamatsu, Niki: The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines. in Journal of cell science 2008
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Human Polyclonal RAB27A Primary Antibody for WB - ABIN1881720
Ohbayashi, Mamishi, Ishibashi, Maruta, Pourakbari, Tamizifar, Mohammadpour, Fukuda, Parvaneh: Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2. in Pigment cell & melanoma research 2010
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Rat (Rattus) Polyclonal RAB27A Primary Antibody for IP, WB - ABIN1742354
Lovis, Roggli, Laybutt, Gattesco, Yang, Widmann, Abderrahmani, Regazzi: Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. in Diabetes 2008
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Rat (Rattus) Polyclonal RAB27A Primary Antibody for IP, WB - ABIN1742353
de Wit, Walter, Milosevic, Gulyás-Kovács, Riedel, Sørensen, Verhage: Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. in Cell 2009
Findings indicate that rab (显示 HRB 抗体) GTP-binding (显示 RND2 抗体) proteins Rab27A and Rab27B (显示 RAB27B 抗体) play significant roles in cell invasion, proliferation, and apoptosis, as well as in chemotherapy resistance.
Here, we report on a new RAB27A genetic anomaly observed in seven Saudi Arabia families that had remained negative after extensive molecular genomic DNA testing. Linkage analysis and targeted sequencing of the RAB27A genomic region in several of these patients led to the identification of a common homozygous tandem duplication of 38 kb affecting exon 2-5 and resulting in a premature stop codon
In comparison with the normal tissues, miR (显示 MLXIP 抗体)-182-5p is expressed at a higher level in gastric cancer (GC) tissues, while RAB27A is expressed at a lower level in cancerous tissues. The down-regulation of miR (显示 MLXIP 抗体)-182-5p and up-regulation of RAB27A can significantly decrease the viability, migration, invasion, and mitosis of HGC-27 cells.
Rab27A is mediated by NF-kappaB (显示 NFKB1 抗体) and promotes stemness of colon cancer cells via up-regulation of cytokine secretion
These results demonstrated that miR (显示 MLXIP 抗体)-145 has an inhibitory role in TNBC malignancy by targeting MMP11 (显示 MMP11 抗体) and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC.
RAB27A, RAB27B (显示 RAB27B 抗体) and VPS36 (显示 VPS36 抗体) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B (显示 RAB27B 抗体) and VPS36 (显示 VPS36 抗体), with RAB27A and RAB27B (显示 RAB27B 抗体) being dependent on VPS36 (显示 VPS36 抗体).
identified small molecule inhibitors of Rab27a-JFC1 (显示 SYTL1 抗体) binding that were also active in cell-based neutrophil-specific exocytosis assays, demonstrating the druggability of Rab (显示 HRB 抗体) GTPases and their effectors.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
decreased expression of Rab27A and Rab27B (显示 RAB27B 抗体), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.
We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).
miR (显示 MLXIP 抗体)-124 has an important role in osteoclastogenesis via targeting Rab27a.
this study shows that Rab27a and Rab27b (显示 RAB27B 抗体) double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
Rab27a is a possible target for intervention in inflammatory processes in which GM-CSF (显示 CSF2 抗体)-dependent neutrophil priming is involved.
These results suggest that the dual effector, Noc2 (显示 RPH3AL 抗体), regulates the transition from Rab2a (显示 RAB2A 抗体)-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
Loss of Rab3D (显示 RAB3D 抗体) from secretory vesicles, leading to disproportionate Rab27-to-Rab3D (显示 RAB3D 抗体) activity, may contribute to the enhanced release of cathepsin S (显示 CTSS 抗体) in tears of patients with Sjogren's syndrome.
The Rab27A regulates CG exocytosis following MII-stage oocyte activation.
Given that GTP (显示 AK3 抗体)- and GDP-bound Rab27a regulate exocytosis.
This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (显示 CACNA1D 抗体) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (显示 VEGFA 抗体) secretion by the retinal pigment epithelium.
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.
RAB27A, member RAS oncogene family
, Ras-related protein Rab-27A
, rab27a, member ras oncogene family
, ras-related protein Rab-27A
, GTP-binding protein Ram
, member RAS oncogene family, RAB27A
, low Mr GTP-binding protein
, ram p25
, RAS oncogene family member