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Human Polyclonal MBOAT4 Primary Antibody for IF (p), IHC (p) - ABIN1714457
Yu, Chu, Chen, Hsieh, Kuo: Mediation of oxidative stress in hypothalamic ghrelin-associated appetite control in rats treated with phenylpropanolamine. in Genes, brain, and behavior 2016
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Human Polyclonal MBOAT4 Primary Antibody for ELISA, WB - ABIN4274728
Takahashi, Ida, Sato, Nakashima, Nakamura, Tsuji, Kojima: Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid. in Journal of biochemistry 2009
Plasma GOAT levels exhibit high specificity/sensitivity to predict prostate carcinoma-presence compared with other PCa (显示 FLVCR1 抗体)-biomarkers, especially in non-diabetic individuals.
The role of ghrelin O-acyltransferase cysteine residue in the ghrelin (显示 GHRL 抗体) acylation
GOAT prefers n-hexanoyl-CoA over n-octanoyl-CoA as the acyl donor, although in the stomach the n-octanoyl form is the predominant form of acyl-modified ghrelin (显示 GHRL 抗体).
The GOAT active site was characterized by defining substrate-enzyme interactions used to bind and recognize ghrelin (显示 GHRL 抗体).
Studies suggest that dysregulation in the components of the ghrelin (显示 GHRL 抗体) system including ghrelin (显示 GHRL 抗体), ghrelin receptor (显示 GHSR 抗体) (GHSR1a) and ghrelin (显示 GHRL 抗体)-O-acyl-transferase can lead to or influence the development and/or progression of highly concerning pathologies.
Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase.
Data indicate that ghrelin O-acyltransferase (GOAT) mRNA and protein are expressed in the normal prostate and prostate cancer tissue samples.
Genetic variation of the ghrelin (显示 GHRL 抗体) activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. (Review)
Identification of GOAT expression in various tissues support the concept that in addition to the important endocrine effect of acylated ghrelin (显示 GHRL 抗体), the paracrine effects of locally synthetised and acylated ghrelin (显示 GHRL 抗体) may be important.
Modulation of GOAT or ghrelin (显示 GHRL 抗体) signaling may be a clinically relevant strategy to treat metabolic diseases such as type II diabetes.
Gene browse revealed QTL for body weight/size, genes involved in immune system, and two main protein-coding genes involved in the Glucose homeostasis, Mboat4 and Leprotl1 (显示 LEPROTL1 抗体). Heritability and coefficient of genetic variance (CVg) were 0.49 and 0.31 for females, while for males, these values 0.34 and 0.22, respectively.
GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in wild-type mice. This was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin (显示 GHRL 抗体) levels. But it was absent in the GHSR1a knockout mouse hippocampus, implying that the expression of GHSR1a may be a prerequisite for the production of GOAT.
Both ghrelin (显示 GHRL 抗体) and GOAT are localized primarily in the red pulp of the spleen. Importantly, in the thymus, ghrelin (显示 GHRL 抗体) was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Both regulates obesity-induced inflammation.
anxiogenic actions of GOAT deletion not related to high plasma des (显示 DES 抗体)-acyl ghrelin (显示 GHRL 抗体)
circadian rhythmicity of ghrelin (显示 GHRL 抗体) signaling requires Bmal1 (显示 ARNTL 抗体) and is driven by a food-responsive clock in the gastric ghrelin (显示 GHRL 抗体)-secreting cell that not only regulates ghrelin (显示 GHRL 抗体), but also GOAT activity.
observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning
Altered lipid and salt taste responsivity in ghrelin (显示 GHRL 抗体) and GOAT null mice.
The absence of GOAT does not alter glucose intolerance suggesting that desacyl/acyl ghrelin (显示 GHRL 抗体) is not a major denominator for glucose homeostasis.
GOAT induced ghrelin (显示 GHRL 抗体) acylation regulates hedonic feeding.
The endogenous GOAT-ghrelin-growth hormone secretagogue receptor (显示 GHSR 抗体) system is not essential for the maintenance of euglycemia during prolonged calorie restriction.
Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.
O-acyltransferase (membrane bound) domain containing 4
, O-acyltransferase domain-containing protein 4
, ghrelin O-acyltransferase
, membrane-bound O-acyltransferase domain-containing protein 4