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The stimulation of inha expression by FSH and the potential inhibition of FSH by inhibin suggest a possible existence of a negative feedback loop between the pituitary and ovary in the zebrafish.
findings report the changes in inhibin-alpha subunit gene expression in the corpus luteum is regulated by LH; results suggest a possible multiple crosstalk of Wnt, cAMP, and SF-1 in the regulation of luteal inhibin secretion
molecular cloning of a novel inhibin alpha cDNA
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (显示 TPM1 蛋白), as a model of immature Leydig cells.
The study is the first to identify an intratesticular role for inhibin/inhibin-alpha subunit, demonstrating that a threshold level of this protein is required for normal testis development and to sustain adult somatic testicular cell function.
inhibin is a broad regulatory marker in anterior pituitary cells
A novel role for GDF9 (显示 GDF9 蛋白) in causing reproductive defects and suppressing tumor initiation in the Inha(-/-) mouse model.
Data indicate that the inhibin-alpha promoter is activated synergistically by Wt1 (显示 WT1 蛋白) and Sf1 (显示 SF1 蛋白).
Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.
relationship between inhibin and Sertoli cell activity
These data support the role of proconvertase PCSK5 in the processing of ovarian inhibin subunits during folliculogenesis.
There are widespread alterations in the transcriptome of gonadotropin-treated Inha-/- granulosa cells, with significant changes in genes involved in extracellular matrix and cell-cell communication.
Results demonstrate that RB is not essential for Sertoli cell tumorigenesis in Inha KO mice but that loss of Inha accelerates the infertility phenotype of Rb cKO mice.
Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.
HIF1A (显示 HIF1A 蛋白) and EPAS1 (显示 EPAS1 蛋白) potentiate hypoxia-induced upregulation of INHA expression in human term cytotrophoblasts in vitro.
There is genetic heterogeneity regarding the INHA gene in different populations, and among the causes of premature ovarian insufficiency. The G769A variant was found in only one patient in the Premature Ovarian Insufficiency Group and in no control, and it appears to be rare in Brazilian patients with premature ovarian insufficiency.
Inhibin-alpha gene is transcriptionally silenced in human leukemia cells. In addition, mutations in, and expression levels of, the inhibin-alpha gene differed between human lymphoid and myeloid leukemia (显示 BCL11A 蛋白) cells.
Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization.
Anti-Mullerian hormone (AMH (显示 AMH 蛋白)) and inhibin-A (INH-A) levels were found to be significantly higher in the polycystic ovary syndrome (PCOS) group compared to the controls.
Immunostaining allowed the identification of specific cell types with E-cadherin (显示 CDH1 蛋白), p53 (显示 TP53 蛋白), and inhibin-alpha expression in all cases.
Each follicular fluid (FF) was individually aspirated and FF/serum EG-VEGF (显示 Prok1 蛋白), inhibin-a, and FF IGF-1 (显示 IGF1 蛋白) levels were evaluated. The pregnant group was characterized by increased numbers of WVFs (p = 0.044), a WVE (p = 0.022), and increased levels of FF IGF-1 (显示 IGF1 蛋白) (p = 0.001) and serum EG-VEGF (显示 Prok1 蛋白) (p = 0.03).
The Sertoli cell hormones inhibin-B and anti Mullerian hormone (显示 AMH 蛋白) have different patterns of secretion in prepubertal cryptorchid boys.
Aberrant methylation and common genetic variation in the INHA promoter occur in human adrenocortical carcinoma and are associated with decreased INHA expression.
Data suggest that, in granulosa cells, inhibin alpha-subunit is involved in regulation of cell proliferation, extracellular matrix remodeling, oogenesis, and ovulation. These studies were conducted in China and involved transcriptome sequencing analysis in cultured granulosa cells (from slaughterhouse pigs) exposed in vitro to a neutralizing anti-inhibin alpha-subunit antibody.
The relationship of INHA insertion/deletion polymorphisms with follicular cysts was investigated
This study provides evidence that the expressions of inhibin alpha subunit and betaglycan (显示 TGFBR3 蛋白) are inferior in cystic follicles, and this may be caused by the decrease in FSH (显示 BRD2 蛋白) in the presence of a cystic follicle.
The c.-42G>A and c.3222G>A polymorphisms in the INHA gene are significantly associated with follicular cysts in sows.
INHA and INHB expression and cellular localization in porcine oocytes were studied.
Association of the INHA gene to ovulation rate.
inhibin alpha-subunits were localized in the granulosa cells of follicles at all stages but were not localized in corpora lutea.
The effects of castration and other surgical intervention on the blood levels of anti-Muellerian hormone (显示 AMH 蛋白), inhibin A, gonadotropins, and gonadotropin receptors in bull calves are reported.
The expression of the components of the activin-inhibin-follistatin (显示 FST 蛋白) system is altered in bovine cystic ovarian disease.
INHA gene can be used as a predictor for superovulation in Chinese Holstein cows.
Inhibin has a negative autocrine or paracrine effect on the in vitro capacity of granulosa cells isolated from dominant or subordinate follicles to produce estradiol.
overexpression of inhibin alpha (1-32) fragment regulated granulosa cell development and effects on subsequent oocyte maturation were both time- and stage-dependent
The result showed that AA genotype had remarkable litter size at P1 locus in the three goat breeds (P < 0.05). Therefore, these results suggest that INHA gene is a strong candidate gene that affects litter size in goats.
Sequence comparison showed that three base changes in INHA(two amino acid substitutions), and three base changes in INHBA (显示 INHBA 蛋白),(one amino acid substitution). No difference seen in INHA or INHBA (显示 INHBA 蛋白) mRNA expression level in the follicle of the two goat breeds.
This gene encodes the alpha subunit of inhibins A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion.
inhibin alpha chain
, inhibin alpha subunit
, inhibin alpha subunit variant 1
, inhibin, alpha
, A-inhibin subunit
, inhibin alpha-subunit
, inhibin A
, inhibin precursor alpha subunit
, Inhibin alpha chain