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Rat (Rattus) Polyclonal GNg13 Primary Antibody for WB - ABIN4895191
Agosto, Anastassov, Robichaux, Wensel: A Large Endoplasmic Reticulum-Resident Pool of TRPM1 in Retinal ON-Bipolar Cells. in eNeuro 2019
Ggamma13 interacts with PDZ domain-containing proteins
G protein gamma subunit, Ggamma13, is expressed in a spatiotemporal manner similar to those of Galphaolf and Galphai2 in the olfactory system and vomeronasal organ, respectively. In addition, Ggamma13 was found in the glomeruli of the main olfactory bulb but was largely absent in the glomeruli of the accessory olfactory bulb; and to play an essential role in odor-triggered social behaviors including male-male aggression.
Differential function of Ggamma13 in rod bipolar and ON cone bipolar cells
The results of this study indicated that Galphaolf exclusively forms a functional heterotrimeric G-protein with Gbeta1 and Ggamma13 in OSNs, mediating olfactory signal transduction
Data suggest that proteins of the taste transduction cascade (alpha-gustducin, G-protein gamma13, and phospholipase Cbeta2) are expressed in testis and are involved in spermatogenesis.
Ggamma13 subunit is coexpressed in physiologically ON-type cone bipolar cells with Gbeta3 and Gbeta4 but is not present in OFF-type bipolar cells.
Gng13 mRNA is highly restricted to the cortex of the XX gonad during sexual differentiation, suggesting a role for this gene during ovarian development.
Ggamma13, a divergent member of the Ggamma subunit family, is abundantly expressed in the cilia of olfactory sensory neurons and and interacts with Ric-8B.
Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006
G gamma subunit, clone:h2-35
, guanine nucleotide binding protein 13, gamma
, guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
, G gamma subunit, clone 2-35