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Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.
The data demonstrate that KLF13 (显示 KLF13 蛋白) is an important component of the transcription network required for heart development and suggest that KLF13 (显示 KLF13 蛋白) is a GATA-4 modifier
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.
The role of GATA4 was elucidated in alcohol dependence susceptibility by identifying rare genetic variants.
disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype
This study attempts to correlate the pattern of intronic variants of GATA4 gene which might provide new insights to unravel the possible molecular etiology of congenital heart disease.
GATA4 induces autocrine BMP2 (显示 BMP2 蛋白) signaling in endothelial cells
study identified a novel mutation in GATA4 that likely contributed to the Congenital Heart Disease in this family. This finding expanded the spectrum of GATA4 mutations and underscored the pathogenic correlation between GATA4 mutations and Congenital Heart Disease.
Hence, the variant distribution of NKX2-5 (显示 NKX2-5 蛋白), GATA4 and TBX5 (显示 TBX5 蛋白) are tightly associated with particular Congenital heart disease subtypes. Further structure-modelling analysis revealed that these mutated amino acid residuals maintain their DNA-binding ability and structural stability
Findings suggest that a single introduction of the three cardiomyogenic transcription factor (GATA4, cand TBX5 (显示 TBX5 蛋白))genes using polyethyleneimine (PEI)-based transfection is sufficient for transdifferentiation of adipose-derived stem cells (hADSCs) towards the cardiomyogenic lineage.
Meta-analysis suggested that GATA4 99 G>T and 487 C>T mutations may not be related to the incidence of congenital heart disease (CHD (显示 CHDH 蛋白)). However, GATA4 354 A>C mutation was significantly associated with CHD (显示 CHDH 蛋白) risk.
common variants in 3'UTR of the GATA4 gene jointly interact, affecting the congenital heart disease susceptibility, probably by altering microRNA posttranscriptional regulation
Our studies suggest that GATA5 (显示 GATA5 蛋白) but especially GATA4 are main contributors to SCN5A (显示 SCN5A 蛋白) gene expression, thus providing a new paradigm of SCN5A (显示 SCN5A 蛋白) expression regulation that may shed new light into the understanding of cardiac disease.
investigation of genes regulated by GATA4, GATA6 (显示 GATA6 蛋白), and both in combination: studies in granulosa cells primed for luteinization
GATA-4 and C/EBPbeta (显示 CEBPB 蛋白) are both required for FSH (显示 BRD2 蛋白) +/- IGF-I (显示 IGF1 蛋白) stimulation of the porcine steroidogenic acute regulatory protein (显示 STAR 蛋白) gene promoter in homologous granulosa cell cultures.
The altered ratio of GATA4 to GATA6 (显示 GATA6 蛋白) after ovulation may allow GATA6 (显示 GATA6 蛋白) to enhance STAR mRNA accumulation.
Mechanistically, decreased GATA4 levels caused the downregulation of several pro-regenerative genes (among them interleukin-13 (显示 IL13 蛋白), Il13 (显示 IL13 蛋白)) in the myocardium.
GATA4 acts as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular competence, which are indispensable for liver development.
study provides novel insights into the role of WT1 (显示 WT1 蛋白) and GATA4 during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
we have identified a distinct lineage of adult HSCs characterized by its derivation of progenitors where Gata4 expression is activated by a specific enhancer. Most adult HSCs belonging to this lineage probably originate in the placenta.
Histone acetylation/methylation and DNA methylation (显示 HELLS 蛋白) were both involved in regulating GATA4 expression, but Nkx2.5 (显示 NKX2-5 蛋白) expression was not regulated by DNA methylation (显示 HELLS 蛋白). These three modifications had high correlation with each other during regulation of GATA4 and produced a regulation loop at the GATA4 promoter.
GATA4 acts as a negative regulator of Bsp (显示 KLK6 蛋白) expression in osteoblasts.
Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs (显示 NR2E3 蛋白) by negatively regulating the Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling pathway and positively regulating the cardiogenic TF Gata4
GATA4 and GATA6 (显示 GATA6 蛋白) are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 and GATA6 (显示 GATA6 蛋白) are also required for the expression of the receptors for prolactin (显示 PRL 蛋白) and luteinizing hormone.
Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine (显示 CCL1 蛋白) signaling.
The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS (显示 ETS1 蛋白) sites.
Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.
ATOH8, GATA4, and FOG2 associate in a single complex
gata4 gene regulates sdf1a (显示 CXCL12 蛋白) levels during early embryogenesis
mga restricts the normal levels of Gata4 required for heart tube looping.
Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma
Gata4 and Gata6 (显示 GATA6 蛋白) have distinct non-redundant functions in cardiac morphogenesis, but are redundant for an early step of liver development; and Gata4 and Gata6 (显示 GATA6 蛋白) are essential and non-redundant for liver growth following initial budding
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 (显示 GATA6 蛋白) or GATA6 (显示 GATA6 蛋白), suggesting redundancy in this family during myocardial development.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
GATA binding protein 4
, glutamyl-tRNA(Gln) amidotransferase subunit A
, GATA-4 zinc-finger transcription factor
, gata4 transcription factor
, GATA-4 transcription factor
, GATA-binding factor 4
, transcription factor GATA-4
, GATA-binding protein 4
, DNA-binding protein GATA-GT2
, transcription factor GATA4
, transcription factor xGATA-4