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Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.
Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.
The data demonstrate that KLF13 (显示 KLF13 蛋白) is an important component of the transcription network required for heart development and suggest that KLF13 (显示 KLF13 蛋白) is a GATA-4 modifier
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 or GATA6, suggesting redundancy in this family during myocardial development.
These results indicate a higher capacity of adipose-derived than bone marrow-derived mesenchymal stem cells to express GATA4.
GATA4 acetylation activated CCND2 (显示 CCND2 蛋白) transcription, and mutation of GATA4 on K-313 reduced cell viability and increased a mitochondria-dependent apoptosis.
the mutation significantly diminished the synergistic activation between MEF2C (显示 MEF2C 蛋白) and GATA4, another cardiac core transcription factor that has been causally linked to Congenital heart disease (CHD (显示 CHDH 蛋白)).
GATA4 was a transcription factor that activated mouse double minute 2 homolog (MDM2 (显示 MDM2 蛋白)) and B cell lymphoma 2 (BCL2 (显示 BCL2 蛋白)) expression in ALL cells.
This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells.
although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2 (显示 GATA2 蛋白), 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy
study found that the formation of pancreatic progenitors cells is highly sensitive to the GATA6 (显示 GATA6 蛋白) and GATA4 gene dosage
when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4.
GATA4 is a regulator of osteoblastic differentiation via the p38 (显示 CRK 蛋白) signaling pathways.
miR (显示 MLXIP 蛋白)-126 inhibits the migration and invasion of glioma cells, which may be linked to GATA4 as a target gene.
Study identified effects of GATA4 variant [(SNP) rs13273672] on regional gray matter (GM) volume in alcohol dependence: higher GM volume in the hypothalamus and caudate in the AA genotype group compared to the AG/GG group. GM volume specific to GATA4 variant predicted heavy relapse risk within 60 d following discharge for both caudate and amygdala and within 90 d for the amygdala only.
investigation of genes regulated by GATA4, GATA6 (显示 GATA6 蛋白), and both in combination: studies in granulosa cells primed for luteinization
GATA-4 and C/EBPbeta (显示 CEBPB 蛋白) are both required for FSH (显示 BRD2 蛋白) +/- IGF-I (显示 IGF1 蛋白) stimulation of the porcine steroidogenic acute regulatory protein (显示 STAR 蛋白) gene promoter in homologous granulosa cell cultures.
The altered ratio of GATA4 to GATA6 (显示 GATA6 蛋白) after ovulation may allow GATA6 (显示 GATA6 蛋白) to enhance STAR mRNA accumulation.
GATA4/6 are key regulators of steroidogenesis and testicular somatic cell survival.
Observations identify Gata4 as a novel crucial regulator of the intestinal epithelial barrier and as a critical epithelial transcription factor implicated in the maintenance of proximal intestinal mucosal integrity after injury.
Gata4 mutants also demonstrated Hedgehog (显示 SHH 蛋白) (Hh) signaling defects.
disruption of GATA4-mediated transactivation in hepatocellular carcinoma suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype
Mechanistically, decreased GATA4 levels caused the downregulation of several pro-regenerative genes (among them interleukin-13 (显示 IL13 蛋白), Il13 (显示 IL13 蛋白)) in the myocardium.
GATA4 acts as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular competence, which are indispensable for liver development.
study provides novel insights into the role of WT1 (显示 WT1 蛋白) and GATA4 during the sex differentiation phase and represents an approach that can be applied to assess other proteins with as yet unknown functions during gonadal development
we have identified a distinct lineage of adult HSCs characterized by its derivation of progenitors where Gata4 expression is activated by a specific enhancer. Most adult HSCs belonging to this lineage probably originate in the placenta.
Histone acetylation/methylation and DNA methylation (显示 HELLS 蛋白) were both involved in regulating GATA4 expression, but Nkx2.5 (显示 NKX2-5 蛋白) expression was not regulated by DNA methylation (显示 HELLS 蛋白). These three modifications had high correlation with each other during regulation of GATA4 and produced a regulation loop at the GATA4 promoter.
GATA4 acts as a negative regulator of Bsp (显示 KLK6 蛋白) expression in osteoblasts.
The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS (显示 ETS1 蛋白) sites.
Study finds that emergent juvenile cortical cardiomyocytes induce expression of gata4 in a manner similar to during regeneration.
ATOH8, GATA4, and FOG2 associate in a single complex
gata4 gene regulates sdf1a (显示 CXCL12 蛋白) levels during early embryogenesis
mga restricts the normal levels of Gata4 required for heart tube looping.
Through the use of a transgenic reporter strain, we found that cardiomyocytes throughout the subepicardial ventricular layer trigger expression of the embryonic cardiogenesis gene gata4 within a week of trauma
Gata4 and Gata6 (显示 GATA6 蛋白) have distinct non-redundant functions in cardiac morphogenesis, but are redundant for an early step of liver development; and Gata4 and Gata6 (显示 GATA6 蛋白) are essential and non-redundant for liver growth following initial budding
Data show that GATA4 knockdown only affects cardiac marker expression in the absence of either GATA5 (显示 GATA6 蛋白) or GATA6 (显示 GATA6 蛋白), suggesting redundancy in this family during myocardial development.
Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
GATA binding protein 4
, glutamyl-tRNA(Gln) amidotransferase subunit A
, GATA-4 zinc-finger transcription factor
, gata4 transcription factor
, GATA-4 transcription factor
, GATA-binding factor 4
, transcription factor GATA-4
, GATA-binding protein 4
, DNA-binding protein GATA-GT2
, transcription factor GATA4
, transcription factor xGATA-4