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These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis .
Both TRPV1 (显示 TRPV1 蛋白) and GRP (显示 UCMA 蛋白) are part of a new mesoaccumbal glutamatergic pathway.
Fos and phosphorylation of extracellular signal-regulated kinases (ERK (显示 EPHB2 蛋白)) were used to look for evidence that interneurons expressing GRP (显示 UCMA 蛋白) were activated following intradermal injection of chloroquine.
GRP (显示 UCMA 蛋白) is expressed by a distinct population of excitatory interneurons in laminae I-II that are likely to be involved in the itch pathway
BNP-NPRA (显示 NPR1 蛋白) signaling is involved in both itch and pain and does not function upstream of the GRP (显示 UCMA 蛋白)-GRPR (显示 GRPR 蛋白) dedicated neuronal pathway.
The majority of dorsal spinal cord Grp is synthesized locally in dorsal spinal cord neurons while Nmb is highly expressed in pain- and itch-sensing dorsal root ganglion neurons.
nonamidated peptides derived from the C terminus of pro-GRP (显示 UCMA 蛋白) are expressed in significant quantities in colorectal cancer cell lines
GRP (显示 UCMA 蛋白) delays the phase of the clock during the early night by prolonging day-like membrane properties of SCN (显示 SRI 蛋白) cells
The GRP (显示 UCMA 蛋白) receptor system does not mediate kappa opioid receptor (显示 OPRK1 蛋白) antagonist (GNTI (显示 MGAT1 蛋白))-induced scratching. The kappa opioid system is involved, at least in part, in the scratch suppressing activity of the kappa opioid receptor (显示 OPRK1 蛋白) agonist nalfurafine.
These studies demonstrate that (64)Cu-SarAr-SA-Aoc-bombesin(7-14) and (64)Cu-SarAr-SA-Aoc-GSG-bombesin(7-14) bound with high affinity to GRPR (显示 GRPR 蛋白)-expressing cells.
GRP may be important both in the endometrial remodeling during the estrous cycle and in the implantation and development of blastocysts
The present results revealed the localization of GRP in the uterine gland cells at light- and electron-microscopic levels and suggested the release of GRP from the cell into the lumen of the gland by exocrine manner.
GRP may be important both in the development of the fetal cervix and secretory activity of the epithelial cells of the cervix.
Both TRPV1 (显示 TRPV1 蛋白) and GRP (显示 LSM4 蛋白) are implied in midbrain physiology of importance to neurological and neuropsychiatric disorders.
GRP/GRP (显示 LSM4 蛋白)-R (显示 GRPR 蛋白) signaling activation contributes to castration-resistant prostate cancer progression
Thus the combination of favourable in vitro and in vivo properties renders BA1 as more potential antagonist bombesin-peptide for targeting GRP (显示 LSM4 蛋白)-receptor positive tumor. These properties are encouraging to carry out further experiments for non-invasive receptor targeting potential diagnostinc and therapeutic agent for tumors.
pro-gastrin releasing peptide has a role in promoting the cell proliferation and progression in small cell lung cancer
Our results suggest that, similar to what happens in neutrophils, gastrin-releasing peptide is a migratory, rather than a proliferative, stimulus, for non-small cell lung carcinoma cells, indicating a putative role for gastrin-releasing peptide and gastrin-releasing peptide receptor (显示 GRPR 蛋白) in metastasis
Serum Pro-GRP (显示 LSM4 蛋白) was promising biomarker for SCLC diagnosis.
CEA (显示 CEACAM5 蛋白), NSE (显示 ENO2 蛋白), CA125 (显示 MUC16 蛋白) and pro-GRP (显示 LSM4 蛋白) could serve as biomarkers for SCLC, and CEA (显示 CEACAM5 蛋白) and CYFRA21-1 could serve as biomarkers for NSCLC. Pro-GRP (显示 LSM4 蛋白), CA125 (显示 MUC16 蛋白) and CEA (显示 CEACAM5 蛋白) were related to the clinical stages of lung cancer
Data show that serum neuron-specific enolase (显示 ENO2 蛋白), cytokeratin 19 (显示 KRT19 蛋白) fragment 21-1, pro-gastrin-releasing peptide, squamous cell carcinoma antigen, tissue inhibitor of metalloproteinase-1, and human epididymis protein 4 are not associated with brain metastases.
No association of 16 GRP (显示 LSM4 蛋白) and 7 GRPR (显示 GRPR 蛋白) variants were found with agoraphobia with/without panic disorder.
the role of autophagy in the degradation of gastrin-releasing peptide and subsequent inhibition of angiogenesis
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms.
, proventricular peptide
, neuromedin C
, pre-progastrin releasing peptide