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These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
LEF-1 (显示 LEF1 蛋白) and CDX2 performed at least as well as beta-catenin (显示 CTNNB1 蛋白), if not better, as a diagnostic marker for pilomatrical carcinomas
Study indicates that CDX2 expression can predict lack of response to NAT (显示 BRD2 蛋白).
CDX2 is not an independent prognostic biomarker in colorectal cancer
This study characterized a new and original variant of the CDX2 homeobox (显示 Lbx1 蛋白) gene.
CDX2 is highly expressed along the atrophic gastritis-metaplasia-dysplasia-cancer sequential. Though CDX2 expression is quite dominant in IM ( intestinal metaplasia), but its expression is not associated with H. pylori (Helicobacter pylori) infection.
of CDX2 using a hypoxia-inducible hTERT promoter-driven vector suppressed malignant progression of colon cancer cells in vitro and in vivo.These results suggest that pLVX-5HRE-hTERTp-CDX2-3FLAG gene therapy may be a promising novel approach to treat colon cancer
The results of the present study show that a lack of CDX2 expression in metastatic colorectal cancer is an adverse prognostic feature and a potential negative predictor of the response to chemotherapy.
We may conclude that hTERT promotes GIM by up-regulating CDX2 via NF-kappaB (显示 NFKB1 蛋白) signaling pathway.
Our work suggests that combination of the consensual CMS (显示 Cd2ap 蛋白) classification and lack of CDX2 expression could be a useful marker to identify CMS4/CDX2-negative patients with a very poor prognosis
AMPK (显示 PRKAA1 蛋白) enhances intestinal barrier function and epithelial differentiation via promoting CDX2 expression, which is partially mediated by altered histone modifications in the Cdx2 promoter.
Data show that SLC7A7 (显示 Slc7a7 蛋白) is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 (显示 Slc7a7 蛋白) promoter.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4 (显示 POU5F1 蛋白), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (显示 POU5F1 蛋白) in embryo of mammals other than mouse
Results reveal an early regulatory switch in Cdx2 expression and show that different inputs are needed to drive Cdx2 expression in the blastocyst trophectoderm and in trophoblast stem cells.
CDX2(Null)/BRAF (显示 BRAF 蛋白)(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF (显示 BRAF 蛋白)(V600E) potently interacted with CDX2 silencing to alter gene expression. Like human serrated lesions, CDX2(Null)/BRAF (显示 BRAF 蛋白)(V600E)-mutant epithelium expressed gastric markers.
including Wnt (显示 WNT2 蛋白) and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx (显示 CDX1 蛋白)/Hox and T Brachyury (显示 TBX1 蛋白) transcriptional networks controls differential axial growth during vertebrate trunk elongation
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha (显示 HNF4A 蛋白) were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha (显示 HNF4A 蛋白) in human biopsy samples.
Cdx (显示 CDX1 蛋白) members interact with the SWI (显示 SMARCA1 蛋白)-SNF (显示 SNRPA 蛋白) complex and make direct contact with Brg1 (显示 SMARCA4 蛋白), a catalytic member of SWI (显示 SMARCA1 蛋白)-SNF (显示 SNRPA 蛋白). Both Cdx2 and Brg1 (显示 SMARCA4 蛋白) co-occupy a number of Cdx (显示 CDX1 蛋白) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 (显示 SMARCA4 蛋白) occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox gene.
Cdx1 (显示 CDX1 蛋白)-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (显示 ADCY10 蛋白) and a block in hematopoietic differentiation from yolk sac (显示 ADCY10 蛋白)-derived cells in culture.
this study shows that Aloe vera (显示 IGF2BP3 蛋白) gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (显示 HOXB7 蛋白) and Cdx2 in colon cancer cells.
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2