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This study validated preoperative serum BChE levels as an independent prognostic factor for urinary tract urothelial carcinoma after radical nephroureterectomy.
we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin (显示 GHRL 蛋白) signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention.
The BChE-K polymorphisms are associated with deleterious changes in cognitive decline in MCI (显示 MCIN 蛋白) patients treated with donepezil for 3 years.
BCHE-K* positive subjects (and APOE (显示 APOE 蛋白)-epsilon4) display an earlier age of onset of Alzheimer's Disease and an accelerated cognitive decline.
Discovery of potent carbonic anhydrase, acetylcholinesterase (显示 AChE 蛋白), and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base.()
Significance of BChE Genetic Variants to Risk of Toxicity from Cholinesterase Inhibitors (review)
Age, sex or smoking status did not influence butyrylcholinesterase activity in a healthy population.
Mutations in the butyrylcholinesterase gene were associated with prolonged effect of succinylcholine or mivacurium.
prolonged apnea after suxamethonium came about as a result of butyrylcholinesterase deficiency or mutation or acquired conditions leading to a decrease in the plasma cholinesterase activity
the molecular mechanisms by which point mutations may lead to silent BChE variant or alter catalytic activity, is reported.
The structure of bovine pancreatic RNase A (显示 RNASE1 蛋白) has been determined in complex with 2'-deoxyguanosine-5'-monophosphateat 1.33 A resolution.
BChE strongly affects fat metabolism, has an important impact on fat accumulation and may be a promising tool for combating obesity.
the absence of BChE leads to diminished fibrillar Abeta (显示 APP 蛋白) deposition in amygdala, hippocampal formation, thalamus and basal ganglia.
It was concluded that in adult murine bone the role of BChE is limited to bone specific changes in microarchitecture and to an increase in relative number of bone resorbing osteoclasts.
Mice that had undergone gene transfer with mouse CocH (显示 COCH 蛋白) (mCocH) showed no place preference or aversion after repeated treatments with a near-lethal 80 mg/kg cocaine dose.
we conclude that toxoplasmosis reduces BChE activity in mice, and this alteration is probably related to the liver damage caused by the parasitism
For metacarb and isocarb, inhibition of BChE w.t. was 260 and 35 times, respectively, faster than inhibition of AChE w.t. For four mutants inhibition was faster than for AChE w.t. but none reached the inhibition rate of BChE.
The localization of BChE in the secondary folds of the neuromuscular junction suggests that this enzyme is not a strict surrogate of AChE and that the two enzymes have two different roles.
The effects of porphyrinogenic drugs on the brain cholinergic system (Ache, Bche, and Chrm1 (显示 CHRM1 蛋白) levels in various regions of the brain) were examined to establish a mechanism for neurological syndrome displayed in acute porphyrias.
A possible mechanism for partial compensation of tetanic fade in acetylcholinesterase (显示 AChE 蛋白) knockout mice is hydrolysis of acetylcholine by normal levels of endogenous butyrylcholinesterase.
The BChE knockout mouse will allow us to test the hypothesis that the function of BChE is to detoxify poisons and will allow testing the role of BChE in other physiological functions.
These findings show that BCHE can hydrolyze 2-Arachidonoylglycerol which may be evidence of a more specific role for BCHE in endocannabinoid regulation.
Data indicate that polyproline peptides of various lengths and sequences are included in the tetramer structure of butyrylcholinesterase, and the function of these polyproline peptides is to serve as tetramer-organizing peptides.
proline-rich peptides organize the 4 subunits of BChE into a 340 kDa tetramer, by interacting with the C-terminal BChE tetramerization domain
Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage.
, acylcholine acylhydrolase
, butyrylcholine esterase
, choline esterase II
, cholinesterase (serum) 2
, cholinesterase 1