Zinc-alpha-2-glycoprotein (human) Matched Pair Detection Set
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- 抗原 See all AZGP1 products
- AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))
- 适用
- 人
- 检测方法
- Colorimetric
- 宿主
- 小鼠
- 实验类型
- Sandwich ELISA
- 检测范围
- 0.0156 ng/mL - 1 ng/mL
- 最低检测浓度
- 0.0156 ng/mL
- 应用范围
- ELISA
- 原理
- Zinc-alpha-2-glycoprotein (human) Matched Pair Detection Set
- 灵敏度
- 100 pg/mL
- 产品特性
- Matched Pair Detection Set. Detects human Zinc-alpha-2-glycoprotein. Does not detect mouse Zinc-alpha-2-glycoprotein. Colorimetric assay. Sample Type: Cell Culture Supernatant, Plasma, Serum. Range: 0.0156 to 1 ng/mL. Sensitivity: 100 pg/mL. Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
- 组件
- 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (120μl) [COAT] 1 vial detection antibody (60μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
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- 限制
- 仅限研究用
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- 浓度
- Lot specific
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
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Short Term Storage: -20°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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- 抗原
- AZGP1 (alpha-2-Glycoprotein 1, Zinc-Binding (AZGP1))
- 别名
- Zinc-alpha-2-glycoprotein (AZGP1 产品)
- 别名
- Zag Matched Antibody Pair, ZA2G Matched Antibody Pair, ZAG Matched Antibody Pair, ZA2GA Matched Antibody Pair, Zna2gp Matched Antibody Pair, alpha-2-glycoprotein 1, zinc Matched Antibody Pair, alpha-2-glycoprotein 1, zinc-binding Matched Antibody Pair, Azgp1 Matched Antibody Pair, AZGP1 Matched Antibody Pair
- 背景
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Alternate Names/Synonyms: Zn-alpha-2-GP, Zn-alpha-2-Glycoprotein, ZAG, ZA2G, AZGP1, ZNGP1
Product Description: Zinc-alpha-2-glycoprotein (ZAG), first identified in the 1960s, derives its name from its precipitation from human plasma upon the addition of zinc salts. ZAG has since been found in secretory epithelial cells and in a range of body fluids. ZAG is identical to a lipid mobilizing factor isolated from the urine of patients with cancer cachexia and stimulates lipolysis in in vitro and in vivo experiments. Due to its expression in, and secretion from adipocytes, ZAG is considered an adipokine. Recently the clinical significance of ZAG has been clarified. ZAG expression in adipocytes is inversely related to fat mass, thus it is intimately involved in the maintenance of body weight in mice and humans. Epidemiological studies have uncovered an association between ZAG and plasma cholesterol. The non-synonymous single nucleotide polymorphism rs4215 in ZAG is associated with plasma cholesterol and obesity. Structurally ZAG possesses a class I major histocompatibility complex (MHC) protein fold. It is distinct from other members of this protein family in that it is soluble, rather than being anchored to plasma membranes, and it associates with prolactin inducible protein rather than beta2-microglobulin. Similar to peptide antigen-presenting class I MHC molecules, ZAG possesses an open apical groove between its alpha1 and alpha2 domain helices.
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