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|抗原||Stratifin (SFN) 抗体|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This Stratifin antibody is conjugated to Alexa Fluor 488 其他选择|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
|Supplier||Log in to see|
Stratifin抗体详情Stratifin目标详情 使用细节 贮存及处理 图像
|纯化方法||Purified by Protein A.|
|免疫原||KLH conjugated synthetic peptide derived from human 14-3-3 sigma|
Stratifin目标详情Stratifin抗体详情 使用细节 贮存及处理 图像 回页首
|别名||14-3-3 sigma (SFN Antibody 摘要)|
14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.
Synonyms: 14 3 3 protein sigma, 14-3-3 protein sigma, 1433S_HUMAN, Epithelial cell marker protein 1, Er, HME 1, HME1, MGC143283, Mkrn3, Mme1, OTTHUMP00000004242, RP23 137L22.11, SFN, SFN protein, Stratin, YWHAS.
|途径||p53 Pathway, Myometrial Relaxation and Contraction|
使用细节Stratifin抗体详情 Stratifin目标详情 贮存及处理 图像 回页首
贮存及处理Stratifin抗体详情 Stratifin目标详情 使用细节 图像 回页首
|缓冲液||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|储存方法||Store at 4°C|