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our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
TCTP (显示 TPT1 蛋白) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.
ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
ATM checkpoint kinase plays a role in telomere maintenance that is independent of telomerase regulation.
Drosophila ATM and Mre11 (显示 MRE11A 蛋白) are essential for the G2/M checkpoint induced by low-dose irradiation.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Dna2 co-localizes in foci with RPA (显示 RPA1 蛋白) and is found in a complex with replication fork components And-1 and Mcm10 (显示 MCM10 蛋白). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (显示 NLRP2 蛋白) and ATM.
ATM and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (显示 MRE11A 蛋白)/Rad50 (显示 RAD50 蛋白)/Nbs1 (显示 NLRP2 蛋白) dependent recovery of collapsed replication forks.
ATM and ATR phosphorylate the functionally critical replication protein Mcm2 (显示 MCM2 蛋白) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (显示 TOPBP1 蛋白) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (显示 TOPBP1 蛋白) with ATR(ATM and Rad3-related).
ATM and ATR control mitotic events in vertebrate cells by targeting CEP63 (显示 CEP63 蛋白) and centrosome dependent spindle assembly.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (显示 TOPBP1 蛋白)-dependent activation of ATR-ATRIP (显示 ATRIP 蛋白) in response to double-stranded DNA breaks.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.
molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM
Characterization of ataxia telangiectasia protein.
Data suggest that ataxia telangiectasia mutated protein (ATM) mutational status in lung cancer is a mechanistic biomarker for MEK (显示 MAP2K1 蛋白) inhibitor response.
Data suggest a close association between the nonfunctionality of ATM/p53 (显示 TP53 蛋白) pathway and accumulation of p27Kip1 (显示 CDKN1B 蛋白) in chronic lymphocytic leukemia (CLL) cells in response to DNA damage.
Letter: BRCA2 (显示 BRCA2 蛋白)- and ATM-mutated prostate cancer sensitive to high dose testosterone.
Radiation-activated ataxia-telangiectasia mutated kinase/p38 (显示 CRK 蛋白) signaling positively contributed to the nucleus to cytosol translocation of HuR (显示 ELAVL1 蛋白).
No significant differences were presented in DNA methylation (显示 HELLS 蛋白) levels of RASSF1A (显示 RASSF1 蛋白) and ATM between the sporadic breast cancer cases and the healthy controls.
The ATM rs189037, rs664677 and rs664143 gene polymorphisms are risk factors for lung cancer, while the ATM rs189037 variant was significantly associated with radiation-induced pneumonitis risk. [meta-analysis]
Moreover, under positive p53 expression, low expression of ATM was highly predictive of poor survival in ACC (p=0.017). CONCLUSION: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic marker for assessing survival rate in patients with ACC [Adenoid cystic carcinoma] of the salivary glands.
results reveal how alterations in FBXO31 (显示 FBXO5 蛋白) phosphorylation, mediated by AKT (显示 AKT1 蛋白) and ATM, underlie physiological regulation of FBXO31 (显示 FBXO5 蛋白) levels in unstressed and genotoxically stressed cells
Combination of T-cell lymphoma-1 (显示 TCL1A 蛋白) protein (TCL1 (显示 TCL1A 蛋白))-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing.
These findings suggested that the ATM/p21 (显示 CDKN1A 蛋白) pathway directly participated in the LDIR-induced cell proliferation inhibition in p53null type prostate tumor cells, whereas this mechanism was absent in normal prostate cells. Thus, p53 (显示 TP53 蛋白) may affect cell stability following LDIR, and plays a crucial role in regulating the ATM/p21 (显示 CDKN1A 蛋白) pathway activated by LDIR.
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT
ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.
ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.
radiation-induced eNOS (显示 NOS3 蛋白) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (显示 HSP90 蛋白)
SOD2 (显示 SOD2 蛋白) expression is ATM- and RelA (显示 NFkBP65 蛋白)-dependent, ATM knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm deletion significantly diminished the expression of Sod2 (显示 SOD2 蛋白).
These data suggest that ATM and ATR are part of the cellular "infrastructure" that maintains the excitatory/inhibitory balance of the nervous system.
ATM has a role in homology-directed repair (HDR (显示 GATA3 蛋白)) independent of the BRCA1 (显示 BRCA1 蛋白)-53BP1 (显示 TP53BP1 蛋白) antagonism; its HDR (显示 GATA3 蛋白) function can become critical in certain contexts
intestinal tuft cells play an important role in regulating the ATM mediated DNA damage response, for epithelial cell survival/self-renewal via a Dclk1 (显示 DCLK1 蛋白) dependent mechanism
in the Atm(-/-) MEFs, the same Radiofrequency electromagnetic fields exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose
ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor (显示 VEGF 蛋白) production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure.
H2AX (显示 H2AFX 蛋白) shows a similar influence as ATM.
The ATM protein is a key mediator of H2O2 preconditioning.
ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (显示 HSP90AA2 蛋白) after exposure ionizing radiation.
These findings define an antagonistic function of ATM and MAPK7 (显示 MAPK7 蛋白) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (显示 MAPK7 蛋白) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
, ataxia telangiectasia mutated
, ataxia telengiesctasia mutated
, ataxia-telangiectasia mutated
, drosophila ATM
, ataxia telangiectasia mutated (includes complementation groups A, C and D)
, ataxia telangiectasia mutated protein
, serine-protein kinase ATM-like
, ataxia telangiectasia mutated (atm)
, A-T mutated
, AT mutated
, TEL1, telomere maintenance 1, homolog
, serine-protein kinase ATM
, Ataxia telangiectasia gene mutated in human beings
, ataxia telangiectasia mutated homolog
, A-T mutated homolog
, ATM (ataxia telangiectasia mutated)
, ataxia telangiectasia gene mutated in human beings