anti-大鼠 ATM 抗体 for Immunofluorescence (Paraffin-embedded Sections)

Recommended ATM Antibody (supplied by: Log in to see )

抗原
Ataxia Telangiectasia Mutated (ATM) 抗体
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ATM serine/threonine kinase L homeolog
  • ATM serine/threonine kinase
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • serine/threonine-protein kinase ATM
  • tefu
  • atm.L
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • LOC5565620
  • MGYG_07634
  • PGTG_14279
  • Atm
抗原表位
AA 2700-2750
90
35
18
17
16
15
10
7
6
6
6
6
5
5
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
368
165
86
29
8
1
1
1
1
宿主

240
107
13
8
3
1
克隆类型
多克隆
标记
This ATM antibody is un-conjugated
12
11
9
8
8
6
5
5
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
应用范围
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
230
144
117
92
84
64
56
44
26
22
12
8
4
4
2
2
2
1
1
选项
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产品编号 ABIN685582
$ 306.90
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN685585 FACS IF (cc) IF (p) Cy3 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN685587 FACS IF (cc) IF (p) Cy5.5 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN685588 FACS IF (cc) IF (p) Cy7 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN685586 FACS IF (cc) IF (p) Cy5 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN685589 FACS IF (cc) IF (p) FITC Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN884036 FACS IF (cc) IF (p) Alexa Fluor 555 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN884037 FACS IF (cc) IF (p) Alexa Fluor 350 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN884038 FACS IF (cc) IF (p) Alexa Fluor 488 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN884039 FACS IF (cc) IF (p) Alexa Fluor 647 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN2808094 FACS IF (cc) IF (p) Alexa Fluor 594 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN679103 IF (p) IHC (p) Rabbit IgG pSer1981 Log in to see Polyclonal 2
1 ABIN4997012 FACS IF (cc) IF (p) Alexa Fluor 680 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0
1 ABIN4997013 FACS IF (cc) IF (p) Alexa Fluor 750 Rabbit IgG AA 2700-2750 Log in to see Polyclonal 0

General

抗原 Ataxia Telangiectasia Mutated (ATM) 抗体
抗原表位 AA 2700-2750
(90), (35), (18), (17), (16), (15), (10), (7), (6), (6), (6), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(368), (165), (86), (29), (8), (1), (1), (1), (1)
宿主
(240), (107), (13), (8), (3), (1)
克隆类型
多克隆
标记 This ATM antibody is un-conjugated
(12), (11), (9), (8), (8), (6), (5), (5), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
应用范围 Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(230), (144), (117), (92), (84), (64), (56), (44), (26), (22), (12), (8), (4), (4), (2), (2), (2), (1), (1)
Pubmed 找到1个引用
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ATM抗体详情

ATM目标详情 使用细节 贮存及处理 References for anti-ATM antibody (ABIN685582) 图像
纯化方法 Purified by Protein A.
免疫原 KLH conjugated synthetic peptide derived from mouse ATM
亚型 IgG
Plasmids, Primers & others

ATM目标详情

ATM抗体详情 使用细节 贮存及处理 References for anti-ATM antibody (ABIN685582) 图像 回页首
抗原
别名 Atm (ATM Antibody 摘要)
背景

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

Subcellular location: Cytoplasm, Nucleus

Synonyms: AI256621, C030026E19Rik, Serine-protein kinase ATM, Ataxia telangiectasia mutated homolog, A-T mutated homolog, Atm

基因ID 11920
UniProt Q62388
途径 p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus

使用细节

ATM抗体详情 ATM目标详情 贮存及处理 References for anti-ATM antibody (ABIN685582) 图像 回页首
应用备注 FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
限制 仅限研究用

贮存及处理

ATM抗体详情 ATM目标详情 使用细节 References for anti-ATM antibody (ABIN685582) 图像 回页首
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months

References for anti-ATM antibody (ABIN685582)

ATM抗体详情 ATM目标详情 使用细节 贮存及处理 图像 回页首
有引用在:

Liu, Yang, Jing, Ren, Wei, Zhang, Zhang, Duan, Zhou, Sun: "Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice." in: Environmental science and pollution research international, Vol. 25, Issue 4, pp. 3423-3434, 2017 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: ovary

图像

ATM抗体详情 ATM目标详情 使用细节 贮存及处理 References for anti-ATM antibody (ABIN685582) 回页首
厂商提供的图像
Immunohistochemistry (IHC) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ATM Polyc...
Immunohistochemistry (IHC) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Formalin-fixed and paraffin embedded human cervical cancer labeled with Anti-ATM Poly...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Image provided by One World Lab validation program. A549 cells probed with Rabbit Ant...