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Study reports that retinoic acid receptor-gamma (RARgamma) is a negative regulator of p53 (显示 TP53 蛋白) signaling and thus extend the oncogenic potential of RARgamma to a new role in controlling the balance between AKT (显示 AKT1 蛋白) and p53 (显示 TP53 蛋白).
the cytoplasmic retinoic acid receptor gamma (RARgamma) controls receptor-interacting protein (显示 RIPK1 蛋白) kinase (显示 CDK7 蛋白) 1 (RIP1 (显示 UQCRFS1 蛋白))-initiated cell death when cellular inhibitor of apoptosis (cIAP) activity is blocked.
Results show that RARgamma expression is significantly upregulated in human hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) tissues and demonstrate that RARgamma could promote HCC (显示 FAM126A 蛋白) invasion and metastasis by regulating E-cadherin (显示 CDH1 蛋白) reduction.
Dual small interfering RNA (siRNA) silencing of RARalpha (显示 RARA 蛋白) and RARgamma reversed RA blockade of P4-induced CK5 (显示 KRT5 蛋白). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (显示 KRT5 蛋白) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis.
A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers.
deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98 (显示 NUP98 蛋白)-RARG-mediated transformation
The current status of knowledge indicates that there might be inter- or overlapping actions between PPARg (显示 PPARG 蛋白) and RARs (显示 RARS 蛋白), and there might be an association of PPARg (显示 PPARG 蛋白)/RARs (显示 RARS 蛋白)(RARa (显示 RARA 蛋白), RARb (显示 RARB 蛋白), and RARg) with renal diseases
RARgamma in concert with ATRA regulates protein levels of CDK1 (显示 CDK1 蛋白) and its subcellular localization.
RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt (显示 AKT1 蛋白)/NF-kappaB (显示 NFKB1 蛋白) and Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) pathways.
RARalpha (显示 RARA 蛋白) and RARgamma reciprocally control K5(+) progenitor cell proliferation and distribution in the developing submandibular salivary epithelium in a cell cycle-dependent manner while regulating lumenization independently of keratinizing differentiation
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (显示 WNT2 蛋白) signalling through physical interactions of RARs (显示 RARS 蛋白) with beta-catenin (显示 CTNNB1 蛋白).
Data show that retinoic acid receptor gamma (RARgamma)-proto-oncogene protein c-fos (c-Fos)-PPARgamma2 (PPARgamma2 (显示 PPARG 蛋白)) signaling rather than reactive oxygen species generation is critical for all-trans retinoic acid (ATRA)-inhibited adipocyte differentiation.
RARgamma plays key roles in the differentiation competence of NGN3 (显示 NEUROG3 蛋白)+ cells in response to retinoic acid during mouse spermatogenesis.
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha (显示 RARA 蛋白) and RARgamma in bone structure regulation.
this study shows that the combination of Rarg and Nr5a2 (显示 NR5A2 蛋白) rapidly promote the iN cell maturation within 1 week and greatly facilitate the conversion with neuronal purities of approximately 50% and yields of >130%.
Data indicate that all three retinoic acid receptor (显示 RARA 蛋白) isoforms RARalha, RARbeta (显示 RARB 蛋白) and RARgamma are expressed in naive CD8 (显示 CD8A 蛋白)+ T cells, as well as CD8 (显示 CD8A 蛋白)+ T cells activated for 48 or 72 h.
erythroid-specific RAR (显示 RARA 蛋白) function is dispensable for erythropoiesis and RARgamma plays an erythroid extrinsic role in erythropoiesis.
Data indicate that male germ cell specific miR (显示 MLXIP 蛋白)-34c might be pivotal in embryonic stem cells (ESCs (显示 NR2E3 蛋白)) differentiation into male germ cells through its target retinoic acid receptor gamma (RARg).
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, nuclear receptor subfamily 1 group B member 3
, retinoic acid nuclear receptor gamma variant 1
, retinoic acid nuclear receptor gamma variant 2
, retinoic acid receptor gamma
, RAR gamma 2
, retinoic acid receptor, gamma
, retinoic acid receptor gamma-like
, RAR gamma
, nuclear receptor subfamily 1 group B member 3-A
, retinoic acid receptor gamma-2
, retinoic acid receptor gamma-A
, zRAR gamma
, RAR-gamma 2.1
, rar gamma
, retinoic acid receptor gamma isoform 2.1