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抗Human MED1 抗体:
抗Mouse (Murine) MED1 抗体:
抗Rat (Rattus) MED1 抗体:
In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR (显示 NR3C1 抗体)) pathway with the genes MED1, HSPA1L (显示 HSPA1L 抗体), GTF2A1 (显示 GTF2A1 抗体) and TAF15 (显示 TAF15 抗体), which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations.
modulation of ESR1 (显示 ESR1 抗体)-MED1 interactions by cAMP signaling plays a critical role in human decidualization.
Our data indicate that MED1 serves as a key mediator in ARv567es induced gene expression
Results show that miR-1 (显示 FSD1 抗体) is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 (显示 MED31 抗体) were overexpressed suggesting that MiR-1 (显示 FSD1 抗体) plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31 (显示 MED31 抗体).
MED1 is required for optimal PRDM16 (显示 PRDM16 抗体)-induced Ucp1 (显示 UCP1 抗体) expression
no association between SCZ and the SNPs of VDR (显示 CYP27B1 抗体), suggesting that VDR (显示 CYP27B1 抗体) is not a major gene for SCZ in Chinese Han population. However, our data indicate a potential involvement of VDR (显示 CYP27B1 抗体) SNPs in the susceptibility of risperidone-treated patients to MetS (显示 ETV3 抗体)
hyperactivated ERK (显示 EPHB2 抗体) and/or AKT (显示 AKT1 抗体) signaling pathways promoted MED1 overexpression in prostate cancer cells.
These results demonstrate a role for MED1 in mediating resistance to the pure anti-estrogen fulvestrant both in vitro and in vivo.
multiple modes of the GATA1 (显示 GATA1 抗体)-MED1 axis may help to fine-tune GATA1 (显示 GATA1 抗体) function during GATA1 (显示 GATA1 抗体)-mediated homeostasis events.
Data concluded that those of VDR ff genotype may be regarded as "low responders" to vitamin D intake in terms of response of circulating 25(OH)D and certain inflammatory biomarkers.
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (显示 MBD4 抗体) plays role in enamel formation; Med1 (显示 MBD4 抗体) induces Alpl (显示 ALPL 抗体) via stimulation of Notch1 (显示 NOTCH1 抗体) signaling by forming Notch1 (显示 NOTCH1 抗体)-RBP-Jk (显示 RBPJ 抗体) complex on Alpl (显示 ALPL 抗体) promoter. (Med1 (显示 MBD4 抗体) = mediator complex subunit 1; Alpl (显示 ALPL 抗体) = alkaline phosphatase, liver-bone-kidney; Notch1 (显示 NOTCH1 抗体) = Notch gene homolog 1 (显示 NOTCH1 抗体); RBP-Jk (显示 RBPJ 抗体) = kappa J region recombining binding protein suppressor of hairless (显示 RBPJ 抗体))
MED1 (显示 MBD4 抗体) in macrophages has an antiatherosclerotic role via PPARgamma (显示 PPARG 抗体)-regulated transactivation.
Cardiomyocyte-specific ablation of Med1 (显示 MBD4 抗体) causes lethal dilated cardiomyopathy in mice.
Med1 (显示 MBD4 抗体) deletion disrupted cardiac mitochondrial and metabolic gene expression patterns
Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop formation, are dynamically recruited to the IgH locus enhancers.
We conclude that MED1 (显示 MBD4 抗体) regulates the temporal progression of primary spermatocytes through meiosis, with its absence resulting in abbreviated pre-leptotene, leptotene, and zygotene stages, and a prolonged pachytene stage.
These results demonstrate that Med1 (显示 MBD4 抗体) is a master regulator in adult stem cells to govern epithelial cell fate
The novel function of MED1 (显示 MBD4 抗体) in keratinocytes.
PRDM16 (显示 PRDM16 抗体) deficiency in BAT (显示 BAAT 抗体) reduces MED1 (显示 MBD4 抗体) binding at PRDM16 (显示 PRDM16 抗体) target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes
Collectively, these observations strongly suggest that MED1 (显示 MBD4 抗体) has an important affect on mitochondrial function.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.
, PPAR binding protein
, PPAR-binding protein
, PPARG binding protein
, TR-interacting protein 2
, activator-recruited cofactor 205 kDa component
, mediator of RNA polymerase II transcription subunit 1
, p53 regulatory protein RB18A
, peroxisome proliferator-activated receptor-binding protein
, thyroid hormone receptor-associated protein complex 220 kDa component
, thyroid hormone receptor-associated protein complex component TRAP220
, thyroid receptor interacting protein 2
, thyroid receptor-interacting protein 2
, vitamin D receptor-interacting protein 230 kD
, vitamin D receptor-interacting protein complex component DRIP205
, calcitonin receptor-stimulating peptide 1
, calcitonin receptor-stimulating peptide-1
, calcitonin-related polypeptide, beta
, mediator complex subunit 1
, peroxisome proliferator-activated receptor binding protein
, membrane component, chromosome 17, surface marker 2
, Ppar binding protein
, peroxisome proliferator activated receptor binding protein