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Loss of ERRgamma in renal epithelial cells Results in Kidney Disease with Cysts.
our present results show an intriguing association between the ESRRG rs1890552 GG genotype and an increased risk of impaired fasting glucose or type 2 diabetes mellitus as well as increased oxidative stress.
It was also associated with beta-cell function (P=1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin (显示 INS 蛋白)-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene
this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription.
Disruption of the orphan receptor (显示 NR1D2 蛋白) ESRRG and disruption of KIAA0825 identified in a subject with hearing loss and mild developmental delay. Given the translocation breakpoints and supporting literature, disruption of ESRRG is the most likely cause for the disorder.
Data suggest that activation of ERRgamma is involved in induction of matrix metalloproteinases 2/9 (MMP2 (显示 MMP2 蛋白) and MMP9 (显示 MMP9 蛋白)) and increased migration/invasiveness of triple-negative breast cancer cells caused by low concentrations of environmental endocrine disruptors (nanomolar bisphenol A used here).
The present results strongly suggest that human nuclear receptor ERRgamma functions as a genuine homomeric dimer with symmetrical dimeric interface regions.
ERRgamma overexpression directs metabolic maturation in human Induced Pluripotent Stem Cells-derived beta-l (显示 INS 蛋白)ike cells.
Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 (显示 CDKN1A 蛋白) and p27 (显示 PAK2 蛋白).
Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines.
MiR (显示 MLXIP 蛋白)-204-5p inhibits myoblast differentiation by targeting MEF2C (显示 MEF2C 蛋白) and ERRgamma.
Muscle ERRgamma over-expression successfully triggered glycolytic-to-oxidative myofiber switch, increased functional mitochondrial content and boosted vascular supply in the db/db (显示 LEPR 蛋白) mice.
The research findings suggest that estrogen-related receptor gamma (ERRgamma) regulates testicular steroidogenesis, both directly controlling and indirectly fine-tuning the expression of steroidogenic genes.
These findings strongly support a role for ERRgamma in the metabolic alterations that underlie the development of diabetic cardiomyopathy.
our results reveal that ERRgamma, induced via activation of the hepatic CB1 (显示 CNR1 蛋白) receptor, is a regulator of hepatic FGF21 (显示 FGF21 蛋白) gene expression and secretion.
Study conclude that O-GlcNAcylation of ERRgamma serves as a major signal to promote hepatic gluconeogenesis.
Mice deficient in beta cell-specific ERRgamma expression are glucose intolerant and fail to secrete insulin (显示 INS 蛋白) in response to a glucose challenge.
ERRgamma plays a key role in vascular calcification by upregulating the BMP2 (显示 BMP2 蛋白) signaling pathway.
Mice lacking neuronal ERRgamma in cerebral cortex and hippocampus exhibit defects in spatial learning and memory.
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors\; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
, estrogen receptor-related protein 3
, nuclear receptor subfamily 3 group B member 3
, estrogen-related receptor gamma
, Usher syndrome 2A (autosomal recessive, mild)
, estrogen-related receptor beta/gamma
, estrogen-related receptor 3
, estrogen-related receptor gamma-like