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Human Polyclonal SRRT Primary Antibody for ELISA, WB - ABIN4281713
Gruber, Olejniczak, Yong, La Rocca, Dreyfuss, Thompson: Ars2 promotes proper replication-dependent histone mRNA 3' end formation. in Molecular cell 2012
Study identified Ars2 as a key component of Drosophila antiviral immunityp; loss of Ars2 in cells, or in flies, increases susceptibility to RNA viruses.
define two mutually exclusive complexes CBC-NELF-E (显示 RDBP 抗体) and CBC-ARS2-PHAX (显示 PHAX 抗体), which likely act in respectively earlier and later phases of transcription
ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II (显示 0 抗体) at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci.
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 (显示 HMOX1 抗体) and ARS2 expression by inhibiting Nrf2 (显示 GABPA 抗体), NF-kappaB (显示 NFKB1 抗体), AP-1 (显示 FOSB 抗体) and MAPK (显示 MAPK1 抗体) pathways in human proximal tubular cells.
Ars2 is overexpressed in HCC (显示 FAM126A 抗体) and may have prognostic value; it might play an important role in HCC (显示 FAM126A 抗体) proliferation and miR (显示 MLXIP 抗体)-21 expression.
ARS2 and CASP8AP2 (显示 CASP8AP2 抗体) expressions can precisely predict high-risk of relapse and ALL prognosis.
Ars2 is overexpressed in human cholangiocarcinoma and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 (显示 PDCD4 抗体) protein levels via the reduction of miR (显示 MLXIP 抗体)-21.
Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA.
These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
Results suggest that FLASH functions in S phase progression through interaction with ARS2.
These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.
ARS2 plays a central role in RNA recognition and processing through multiple protein and RNA interactions.
findings reveal Ars2 as a new transcription factor that controls the multipotent progenitor state of NSCs through direct activation of the pluripotency factor Sox2 (显示 SOX2 抗体)
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA)\; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
, Arsenite-resistance protein 2-A
, serrate RNA effector molecule homolog A
, arsenate resistance protein 2
, arsenate resistance protein ARS2
, arsenite resistance protein
, arsenite-resistance protein 2
, serrate RNA effector molecule homolog
, Arsenite-resistance protein 2