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Human Polyclonal SRRT Primary Antibody for ELISA, WB - ABIN4281713
Gruber, Olejniczak, Yong, La Rocca, Dreyfuss, Thompson: Ars2 promotes proper replication-dependent histone mRNA 3' end formation. in Molecular cell 2012
Study identified Ars2 as a key component of Drosophila antiviral immunityp; loss of Ars2 in cells, or in flies, increases susceptibility to RNA viruses.
Deletion of Ars2 from adult mice resulted in defective hematopoiesis in bone marrow and thymus.Ars2 was required for survival of developing thymocytes and for limiting differentiation of bone marrow resident long-term hematopoietic stem cells. Ars2 knockout led to rapid thymic involution and loss of the ability of mice to regenerate peripheral blood after myeloablation.
Ars2 deficiency inhibited the activation of the MAPK/ERK pathway, leading to cell cycle arrest in the G1 phase, resulting in suppression of glioblastoma cell proliferation.
Study present the human ARS2 crystal structure, which exhibits similarities and metazoan-specific differences to the plant homologue SERRATE, most notably an additional RRM domain. RRM domain is required to bind RNA, whereas a basic patch in the C-terminal leg of ARS2 mediates the interaction with FLASH.
define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription
ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci.
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells.
Ars2 is overexpressed in HCC and may have prognostic value; it might play an important role in HCC proliferation and miR-21 expression.
ARS2 and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis.
Ars2 is overexpressed in human cholangiocarcinoma and may be a diagnostic marker. Ars2 depletion increases PTEN and PDCD4 protein levels via the reduction of miR-21.
Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA.
These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
Results suggest that FLASH functions in S phase progression through interaction with ARS2.
These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.
Validated occurrence of an unusual TG 3' splice site in intron 17 (NM_015908).
Nomenclature. Original paper and GenBank submission by Rossman and Wang (1999) called the gene Asr2 (arsenite resistance protein 2) as opposed to Ars2 (arsenate resistance protein 2).
ARS2 plays a central role in RNA recognition and processing through multiple protein and RNA interactions.
findings reveal Ars2 as a new transcription factor that controls the multipotent progenitor state of NSCs through direct activation of the pluripotency factor Sox2
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA)\; however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).
, Arsenite-resistance protein 2-A
, serrate RNA effector molecule homolog A
, arsenate resistance protein 2
, arsenate resistance protein ARS2
, arsenite resistance protein
, arsenite-resistance protein 2
, serrate RNA effector molecule homolog
, Arsenite-resistance protein 2