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Variants rs2270226 and rs2077777 in the RBPJ gene were associated with the risk of cerebral infarction diseases in the Chinese Han population.
RBPJ and MAML3 could be new therapeutic targets for SCLC.
The ULK3 (显示 ULK3 蛋白) Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL (显示 CSHL1 蛋白) and GLI (显示 GLI1 蛋白)
Notch1 signaling plays an important role in the maintenance of the cancer stem-like phenotype in diffuse type gastric cancer through an RBP-Jkappa dependent pathway; inhibiting Notch1 signaling could be an effective therapy against CD133 positive diffuse type gastric cancers
We show that GIT1, which also contains an ANK domain, inhibits the Notch1 (显示 NOTCH1 蛋白)-Dll4 (显示 DLL4 蛋白) signaling pathway by competing with Notch1 (显示 NOTCH1 蛋白) ANK domain for binding to RBP-J in stalk cells
we report that genetic removal of CSL (显示 CSHL1 蛋白) in breast tumor cells caused accelerated growth of xenografted tumors. Loss of CSL (显示 CSHL1 蛋白) unleashed a hypoxic response during normoxic conditions, manifested by stabilization of the HIF1alpha (显示 HIF1A 蛋白) protein and acquisition of a polyploid giant-cell, cancer stem cell-like, phenotype.
RBPJ interacts with L3MBTL3 (显示 L3MBTL3 蛋白) to promote repression of Notch (显示 NOTCH1 蛋白) signaling via histone demethylase (显示 MBD2 蛋白) KDM1A (显示 KDM1A 蛋白).
RBPJ links MYC (显示 MYC 蛋白) and transcriptional control through CDK9 (显示 CDK9 蛋白) in brain tumors, providing potential nodes of fragility for therapeutic intervention, potentially distinct from NOTCH (显示 NOTCH1 蛋白)
Mean CBF1 expression is significantly increased in isocitrate dehydrogenase 1 (IDH1 (显示 IDH1 蛋白)) R132H mutant glioblastoma. Hypoxic regions of glioblastoma have higher CBF1 activation and exposure to low oxygen can induce its expression in glioma cells in vitro.
structural and biophysical studies demonstrate that RITA (显示 ZNF331 蛋白) binds RBP-J similarly to the RAM (显示 RAB27A 蛋白) (RBP-J-associated molecule) domain of Notch (显示 NOTCH1 蛋白), our biochemical and cellular assays suggest that RITA (显示 ZNF331 蛋白) interacts with additional regions in RBP-J.
Early pancreatic islet fate and maturation is controlled through RBP (显示 RBP4 蛋白)-Jkappa.
In this study, the authors found that conditional disruption of RBP-J, the transcription factor of canonical Notch (显示 NOTCH1 蛋白) signaling, increased irradiation sensitivity in mice.
Data (including data from studies in transgenic mice) suggest that signaling via Notch2 (显示 NOTCH2 蛋白) and Notch3 (显示 NOTCH3 蛋白) plays role in promoting cell differentiation and steroidogenesis in preovulatory granulosa cells; mechanism involves regulation of gene expression of Jag1 (显示 JAG1 蛋白) and Rbpj. (Notch2 (显示 NOTCH2 蛋白) = Notch2 (显示 NOTCH2 蛋白) receptor; Notch3 (显示 NOTCH3 蛋白) = Notch3 (显示 NOTCH3 蛋白) receptor; Jag1 (显示 JAG1 蛋白) = jagged-1 (显示 JAG1 蛋白) protein; Rbpj = recombining binding protein suppressor of hairless)
Macrophage maturation is controlled by Notch ligand (显示 JAG2 蛋白) Dll1 (显示 DLL1 蛋白) expressed in vascular endothelial cells of arteries and requires macrophage canonical Notch (显示 NOTCH1 蛋白) signaling via Rbpj, which simultaneously suppresses an inflammatory macrophage fate. Conversely, conditional mutant mice lacking Dll1 (显示 DLL1 蛋白) or Rbpj show proliferation and transient accumulation of inflammatory macrophages, which antagonizes arteriogenesis and tissue repair.
RBPJ binds and trans-activates the Il23r (显示 IL23R 蛋白) promoter and induces IL-23R (显示 IL23R 蛋白) expression and represses anti-inflammatory IL-10 (显示 IL10 蛋白) production in Th17 cells.
RBP-J deficiency drastically reduced dopamine release in the striatum and caused a subtle decrease in the number of dopaminergic neurons. These findings demonstrated that Notch (显示 NOTCH1 蛋白)/RBP-J signaling regulates dopamine responsiveness in the striatum, which may explain the mechanism whereby Notch (显示 NOTCH1 蛋白)/RBP-J signaling affects an individual's susceptibility to neuropsychiatric disease.
RBP-J-mediated Notch (显示 NOTCH1 蛋白) signalling is critical for basophil-dependent immunoregulation. Deficiency of RBP-J influences the immunoregulatory functions of BA, which include activation of T cells and their differentiation into T helper cell subtypes.
Data, including data from studies using cells from transgenic/knockout mice, suggest that Med1 (显示 MBD4 蛋白) plays role in enamel formation; Med1 (显示 MBD4 蛋白) induces Alpl (显示 ALPL 蛋白) via stimulation of Notch1 (显示 NOTCH1 蛋白) signaling by forming Notch1 (显示 NOTCH1 蛋白)-RBP-Jk complex on Alpl (显示 ALPL 蛋白) promoter. (Med1 (显示 MBD4 蛋白) = mediator complex subunit 1 (显示 MED1 蛋白); Alpl (显示 ALPL 蛋白) = alkaline phosphatase, liver-bone-kidney; Notch1 (显示 NOTCH1 蛋白) = Notch gene homolog 1 (显示 NOTCH1 蛋白); RBP-Jk = kappa J region recombining binding protein suppressor of hairless)
study uncovered a regulatory network, where miR (显示 MLXIP 蛋白)-182 functions as an important new node that receives inputs from RBP-J and TNF-alpha (显示 TNF 蛋白) signaling and positively regulates inflammatory osteoclastogenesis; suppression of miR (显示 MLXIP 蛋白)-182 by RBP-J serves as an important mechanism that restrains TNF-alpha (显示 TNF 蛋白) induced osteoclastogenesis
structural and biophysical studies demonstrate that RITA (显示 C12orf52 蛋白) binds RBP-J similarly to the RAM (显示 FAM103A1 蛋白) (RBP-J-associated molecule) domain of Notch (显示 NOTCH1 蛋白), our biochemical and cellular assays suggest that RITA (显示 C12orf52 蛋白) interacts with additional regions in RBP-J.
findings reveal that, in response to Wnt (显示 WNT2 蛋白) signalling, Dishevelled (显示 DVL2 蛋白) inhibits CSL (显示 SMPX 蛋白) transcription factors to regulate Notch (显示 NOTCH1 蛋白) signalling and cell-fate decisions in vivo
The study reports the identification and functional characterization of rbpj interacting and tubulin associated (RITA) (C12ORF52 (显示 C12orf52 蛋白)) as a novel rbpj/CBF-1-interacting protein.
The results suggest that a cell-to-cell interaction via the Notch (显示 NOTCH1 蛋白)/Su(H) pathway has a significant role in the PGC (显示 PGC 蛋白) migration by regulating cell motility.
This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H) mRNA.
Intronic Flk1 (显示 KDR 蛋白) genetic enhancer element directs arterial-specific expression via RBPJ-mediated venous repression.
embryos treated with morpholinos against wt1a, foxc1a, or the Notch (显示 NOTCH1 蛋白) transcriptional mediator rbpj develop fewer podocytes, as determined by wt1b (显示 WT1 蛋白), hey1 (显示 HEY1 蛋白) and nephrin (显示 NPHS1 蛋白) expression, while embryos deficient in any two of these factors completely lack podocytes
her8a is positively regulated by Su(H)-dependent Notch (显示 NOTCH1 蛋白) signaling as revealed by a Notch (显示 NOTCH1 蛋白)-defective mutant and injection of variants of the Notch (显示 NOTCH1 蛋白) intracellular regulator, Su(H).
analysed the function of Su(H) in the somitogenesis process and its influence on the expression of notch (显示 NOTCH1 蛋白) pathway genes
one element of the Notch (显示 NOTCH1 蛋白) signalling pathway, Su(H), is required for control of retinoic acid metabolism in the tailbud
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.
, H-2K binding factor-2
, RBP-J kappa
, immunoglobulin kappa J region recombination signal binding protein 1
, recombining binding protein suppressor of hairless
, renal carcinoma antigen NY-REN-30
, suppressor of hairless homolog
, J kappa-recombination signal-binding protein
, suppressor of hairless protein 1
, suppressor of hairless protein homolog
, recombination signal binding protein for immunoglobulin kappa J region a
, suppressor of hairless 2
, recombining binding protein suppressor of hairless-like