PEN2 抗体
(Presenilin Enhancer 2 Homolog (PSENEN))
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008].
recommended
PSENEN 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
recommended
recommended
PEN2 抗体 by 应用范围
Find PEN2 抗体 validated for a specific application such as WB, IF (cc), IF (p), ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.
PEN2 抗体 by 抗体来源
Find PEN2 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
PEN2 抗体 by 抗原表位
Find PEN2 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.
PEN2 抗体 by 克隆形成能力
Find available monoclonal or polyclonal PEN2 抗体. Click on a link to go to the corresponding products.
PEN2 抗体 by 克隆
Find PEN2 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
Popular PEN2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN1387540
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7139851
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN565943
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Horse, Human, Mouse, Opossum, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN960316
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Xenopus laevis, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
Cat. No.
ABIN6746582
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit
Application
WB
Validations
- (1)
Cat. No.
ABIN6747253
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (2)
Cat. No.
ABIN2788066
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, EIA
Validations
- (2)
Cat. No.
ABIN500471
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN500473
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN1397397
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN5008661
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN5008662
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN1397393
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN1397394
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN1397395
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our PEN2 抗体
: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." in: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).
: "PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 7850-4, (2003) (PubMed).
: "Membrane topology of gamma-secretase component PEN-2." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 20117-23, (2003) (PubMed).
: "The role of presenilin cofactors in the gamma-secretase complex." in: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).
: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." in: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).
: "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation." in: Developmental cell, Vol. 3, Issue 1, pp. 85-97, (2002) (PubMed).
Aliases for PEN2 抗体
presenilin enhancer gamma-secretase subunit (PSENEN) 抗体presenilin enhancer 2 (PEN2) 抗体
presenilin enhancer 2 (Psenen) 抗体
presenilin enhancer gamma secretase subunit (Psenen) 抗体
Gamma-secretase subunit pen-2 (pen-2) 抗体
presenilin enhancer (pen-2) 抗体
presenilin enhancer gamma secretase subunit S homeolog (psenen.S) 抗体
presenilin enhancer gamma secretase subunit (psenen) 抗体
presenilin enhancer gamma-secretase subunit (Psenen) 抗体
1700023M09Rik 抗体
ACYPI006208 抗体
anon-AE003800.1 抗体
CG33198 抗体
Dmel\\CG33198 抗体
dPen-2 抗体
MSTP064 抗体
PEN-2 抗体
Pen-2 抗体
pen-2 抗体
PEN2 抗体
pen2 抗体
Psenen 抗体
psenen 抗体
RGD1312037 抗体
zgc:109727 抗体
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