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NOTCH4 抗体

(Notch 4 (NOTCH4))
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008].
NOTCH4 抗体  (AA 1715-2001) NOTCH4 抗体  (AA 1715-2001) NOTCH4 抗体 (AA 1715-2001) (ABIN7442495)

NOTCH4 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

NOTCH4 抗体  (Middle Region) NOTCH4 抗体  (Middle Region) NOTCH4 抗体 (Middle Region) (ABIN2777550)

NOTCH4 适用: 人, 大鼠, Cow, 马, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated

NOTCH4 抗体 NOTCH4 抗体 NOTCH4 抗体 (ABIN7254322)

NOTCH4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

NOTCH4 抗体 by Grade

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NOTCH4 抗体 by 适用

Find NOTCH4 抗体 for a variety of species such as anti-Human NOTCH4, anti-Mouse NOTCH4, anti-Rat NOTCH4. The species listed below are among those available. Click on a link to go to the corresponding products.

NOTCH4 抗体 by 应用范围

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NOTCH4 抗体 by 抗原表位

Find NOTCH4 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

NOTCH4 抗体 by 克隆形成能力

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NOTCH4 抗体 by 克隆

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NOTCH4 抗体 by 标记

Find NOTCH4 抗体 with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular NOTCH4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
  • (6)
Cat. No. ABIN7442495
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Guinea Pig, Horse, Human, Pig, Rat
Application WB, IHC
Validations
  • (3)
  • (4)
Cat. No. ABIN2777550
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7254322
Quantity 200 μL
Datasheet Datasheet
Reactivity Cow, Guinea Pig, Horse, Human, Pig
Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN6741546
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, IF
Validations
  • (2)
Cat. No. ABIN768617
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6144740
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Pig, Rabbit
Application WB, IHC
Validations
  • (1)
  • (2)
Cat. No. ABIN2779440
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7185236
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6243916
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN7264327
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN3181823
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN791084
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1980477
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN3032033
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Mouse, Rat
Application ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro)
Validations
Cat. No. ABIN6989410
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our NOTCH4 抗体

Gelsomino, Panza, Giordano, Barone, Gu, Spina, Catalano, Fuqua, Andò: "Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines." in: Cancer letters, Vol. 428, pp. 12-20, (2018) (PubMed).

Bhat, Sun, Weger, Raouf: "Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells." in: Stem cells and development, Vol. 25, Issue 7, pp. 522-9, (2016) (PubMed).

Soylu, Acar, Ozbey, Unal, Koksal, Bassorgun, Ciftcioglu, Ustunel: "Characterization of Notch Signalling Pathway Members in Normal Prostate, Prostatic Intraepithelial Neoplasia (PIN) and Prostatic Adenocarcinoma." in: Pathology oncology research : POR, Vol. 22, Issue 1, pp. 87-94, (2015) (PubMed).

Sun, Klauzinska, Lake, Lee, Santopietro, Raafat, Salomon, Callahan, Artavanis-Tsakonas: "Trp53 regulates Notch 4 signaling through Mdm2." in: Journal of cell science, Vol. 124, Issue Pt 7, pp. 1067-76, (2011) (PubMed).

Sekine, Moriyama, Koyanagi, Koyama, Ogata, Okumura, Yagita: "Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands." in: International immunology, Vol. 21, Issue 3, pp. 295-301, (2009) (PubMed).

Tang, Urs, Liaw: "Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site." in: Circulation research, Vol. 102, Issue 6, pp. 661-8, (2008) (PubMed).

Murphy, Lam, Wu, Kim, Vartanian, Bollen, Carlson, Wang: "Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10901-6, (2008) (PubMed).

Moriyama, Sekine, Koyanagi, Koyama, Ogata, Chiba, Hirose, Okumura, Yagita: "Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice." in: International immunology, Vol. 20, Issue 6, pp. 763-73, (2008) (PubMed).

Bray: "Notch signalling: a simple pathway becomes complex." in: Nature reviews. Molecular cell biology, Vol. 7, Issue 9, pp. 678-89, (2006) (PubMed).

Takahashi, Cui, Kojima, Han, Yu, Tanabe, Yara, Matsuura, Matsushima, Nakayama, Arinami, Shen, Faraone, Tsuang: "Family-based association study of the NOTCH4 gene in schizophrenia using Japanese and Chinese samples." in: Biological psychiatry, Vol. 54, Issue 2, pp. 129-35, (2003) (PubMed).

Aliases for NOTCH4 抗体

notch 4 (NOTCH4) 抗体
notch 4 (Notch4) 抗体
neurogenic locus notch homolog protein 4 (LOC100712850) 抗体
Int-3 抗体
INT3 抗体
Int3 抗体
N4 抗体
NOTCH3 抗体
Notch4 抗体
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