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抗Human FURIN 抗体:
抗Mouse (Murine) FURIN 抗体:
抗Rat (Rattus) FURIN 抗体:
Cow (Bovine) Polyclonal FURIN Primary Antibody for ELISA, WB - ABIN2473713
Bray: Notch signalling: a simple pathway becomes complex. in Nature reviews. Molecular cell biology 2006
Human Polyclonal FURIN Primary Antibody for ELISA, WB - ABIN4312814
Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007
Silencing furin genes reduced the survival of M. marinum-infected zebrafish embryos. A mycobacterial infection upregulated furinA in adult zebrafish.
Genetic analysis of fin development in zebrafish identifies furin as potential novel fraser syndrome disease genes
furin genes may function partially redundantly to activate Endothelin1 signaling in craniofacial patterning
the furin inhibitor dec-RVKR-CMK (显示 CXCL9 抗体) blocked entry of MERS-CoV harboring an S protein (显示 CDSN 抗体) lacking furin cleavage sites; it even blocked entry into furin-deficient LoVo cells. In addition, dec-RVKR-CMK (显示 CXCL9 抗体) inhibited not only the enzymatic activity of furin but also those of cathepsin L (显示 CTSL1 抗体), cathepsin B (显示 CTSB 抗体), trypsin, papain, and TMPRSS2 (显示 TMPRSS2 抗体).
Using protein X-ray crystallography, this study investigated the extended substrate binding site of furin in complex with three peptide-derived inhibitors at up to 1.9 A resolution.
In squamous cell carcinoma of the cervix (SCCC), higher levels of MMP-14 (显示 MMP14 抗体) expression were established in tumor cells, as evidenced by IHC (+3) and RT-PCR.Furin activity in the tumor was much higher than that in normal tissues. The expression of TIMP-2 (显示 TIMP2 抗体) mRNA was sufficiently obvious in both the tumor and normal tissues to the bottom of the uterine cavity.
these findings identify furin as an important factor for aRMS progression and survival. Thus, we propose furin as a novel therapeutic target for treatment of aRMS.
Novel protein crystallographic structures of the prototypical PC family member furin in different functional states were determined to 1.8-2.0 A.
findings uncover a role of ERK1 (显示 MAPK3 抗体) in the regulation of furin activity by supporting a self-sustaining loop for high TGF-beta (显示 TGFB1 抗体) activity in glioma-initiating cells.
Divers studies have confirmed the expression of furin in a large spectrum of cancers. Functional studies modulating its activity uncovered its importance for the processing of many cancer-related substrates and strongly indicate that high furin activity promotes the malignant phenotype of cancer cells. [review]
Furin plays an important role in the malignant phenotype of rhabdomyosarcoma cells by activating proteins involved in tumor growth, vascularization, metastasis and invasion.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells probably via Hippo-YAP (显示 YAP1 抗体) pathway and may be a potential target for anti-pancreatic cancer.
Results suggest that (pro)renin receptor (显示 ATP6AP2 抗体) (s(P)RR (显示 ATP6AP2 抗体)) is generated by sequential processing by site-1 protease (S1P (显示 MBTPS1 抗体)) and furin protein.
The developmental arrest of early secondary follicles following furin disruption might be rooted in the loss of the mature form of ADAMTS1 (显示 ADAMTS1 抗体) and compromised proliferation of granulosa cells in mutant mice.
FURIN has an anti-inflammatory function in LysM+ myeloid cells in vivo.
The proprotein convertase furin is responsible for pro-OCN maturation in vitro and in vivo.
Studied the impact of Furin inhibition on the development and progression of hepatocellular carcinoma.
PC7 (显示 PCSK7 抗体) and the related proteases Furin and Pace4 (显示 PCSK6 抗体) regulate E-cadherin (显示 CDH1 抗体) function during blastocyst formation.
work confirms the hypothesis that the TCR-regulated protease FURIN plays an important role in T cell activation and that it can specifically modulate TCR-activated transactivation
the role of serpinB8 (显示 SERPINB8 抗体)/furin in obesity-associated chronic inflammation
Furin has a role as the primary in vivo convertase of ANGPTL3 (显示 ANGPTL3 抗体) and endothelial lipase (显示 LIPG 抗体) in hepatocytes
overexpression of PCs, furin and PC5 (显示 PCSK5 抗体), but not PC7 (显示 PCSK7 抗体), which are all expressed in SMC (显示 DYM 抗体), increase PKGI (显示 PRKG1 抗体) cleavage in a dose-dependent manner
Point mutation of the furin cleavage site at the S2' position of the S protein enables the virus to infect cultured cells independently of trypsin.
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene.
furin (paired basic amino acid cleaving enzyme)
, furin A
, furin B
, FES upstream region
, dibasic processing enzyme
, dibasic-processing enzyme
, furin, membrane associated receptor protein
, paired basic amino acid residue-cleaving enzyme
, proprotein convertase subtilisin/kexin type 3
, paired basic amino acid residue cleaving enzyme
, prohormone convertase 3
, subtilisin pro-protein processing enzyme
, paired basic amino acid cleaving enzyme
, trans Golgi network protease furin
, Paired basic amino acid cleaving enzyme (furin)
, Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)
, proprotein convertase subtilisin/kexin type3